التفاصيل البيبلوغرافية
| العنوان: |
Chapter Six - Combinatorial Cancer Immunotherapies. |
| المؤلفون: |
Hellmann, Matthew D., Friedman, Claire F., Wolchok, Jedd D. |
| المصدر: |
Advances in Immunology; Apr2016, Vol. 130, p251-277, 27p |
| مصطلحات موضوعية: |
CANCER immunotherapy, T cells, CANCER patients, CANCER treatment, PROGRAMMED cell death 1 receptors, CYTOTOXIC T lymphocyte-associated molecule-4, THERAPEUTICS |
| مستخلص: |
T cell checkpoint blockade therapies are revolutionizing the treatment of patients with cancer. Highlighted by the recent success of PD-1 plus CTLA-4 blockade in patients with melanomas, synergistic immunotherapy combinations of modalities represent an important opportunity to improve responses and outcomes for patients. We review the rationale and experience with T cell checkpoint blockade in combination with targeting of other coinhibitory or costimulatory checkpoints, immunomodulatory molecules in the tumor microenvironment, and other anticancer modalities such as vaccines, chemotherapy, and radiation. [ABSTRACT FROM AUTHOR] |
|
Copyright of Advances in Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
