Pathobiology of Hodgkin Lymphoma
| العنوان: | Pathobiology of Hodgkin Lymphoma |
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| المؤلفون: | Simona Righi, Anna Gazzola, Maria Antonella Laginestra, Elena Sabattini, Francesco Bacci, Carlo A. Sagramoso-Sacchetti, Claudio Agostinelli, Claudia Mannu, Pier Paolo Piccaluga, Maria Rosaria Sapienza, Maria Teresa Sista, Claudio Tripodo, Stefano Pileri, Maura Rossi |
| المساهمون: | Piccaluga P.P., Agostinelli C., Gazzola A., Tripodo C., Bacci F., Sabattini E., Sista M.T., Mannu C., Sapienza M.R., Rossi M., Laginestra M.A., Sagramoso-Sacchetti C.A., Righi S., Pileri S.A., Piccaluga, PP, Agostinelli, C, Gazzola, A, Tripodo, C, Bacci, F, Sabattini, E, Sista, MT, Mannu, C, Sapienza, MR, Rossi, M, Laginestra, MA, Sagramoso-Sacchetti, CA, Righi, S, Pileri, SA |
| المصدر: | Advances in Hematology Università degli Studi di Palermo-IRIS Advances in Hematology, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Publishing Corporation, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, business.industry, Mixed cellularity, Lymphocyte, Hematology, Review Article, Histogenesis, medicine.disease, Phenotype, Virus, Lymphoma, Pathobiology, medicine.anatomical_structure, hemic and lymphatic diseases, medicine, Hodgkin lymphoma, Diseases of the blood and blood-forming organs, RC633-647.5, business, Who classification, microenvironment |
| الوصف: | Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1687-9112 1687-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb234f1a27198b026e4651e2256508e3Test http://europepmc.org/articles/PMC3021869Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb234f1a27198b026e4651e2256508e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16879112 16879104 |
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