Prevention of Hearing Loss by Alteration of the Systemic Immune System
| العنوان: | Prevention of Hearing Loss by Alteration of the Systemic Immune System |
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| المؤلفون: | Tomofumi Sakagami, Y. Yun, Hiroshi Iwai, Akira Kanda, Yoshiki Kobayashi, Kensuke Suzuki, Muneo Inaba, D. B. Van |
| المصدر: | Advances in Aging Research. :29-41 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Hearing loss, business.industry, Lymphocyte, Ocean Engineering, Inflammation, Interleukin 1 receptor, type II, Immunosenescence, medicine.disease_cause, Autoimmunity, medicine.anatomical_structure, Immune system, Immunology, medicine, Inner ear, medicine.symptom, business |
| الوصف: | Although congenital sensorineural hearing loss (SHL) in the bilateral cochleae mainly results from genetic abnormalities, chronic SHL progressing in later life is often influenced by systemic immune disturbances, including autoimmunity, chronic inflammation, and immunosenescence. We have investigated the relationship between the inner ear and systemic immunity and reviewed the possibilities to prevent SHL, including autoimmune SHL and age-related SHL. We also demonstrated two lymphocyte populations, interleukin 1 receptor type II (IL-1R2)-positive T cells (T1R2) and naturally occurring regulatory T cells (nTregs) in CD4+ T cells, which increase with aging, suppress host immune function and promote organ degeneration. Alterations in systemic immunity by fewer microbial antigen challenges in the living environment, elimination of immune suppressive lymphocytes, or immune rejuvenation with a reconstituted thymus may contribute not only to renew the cochlear function in SHL, but also to extend the healthy life of functional organs in a vigorous and youthful body, one of humanity’s greatest dreams. |
| تدمد: | 2169-0502 2169-0499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e5654c934497b26df9773fc762e0e599Test https://doi.org/10.4236/aar.2019.82003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........e5654c934497b26df9773fc762e0e599 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21690502 21690499 |
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