التفاصيل البيبلوغرافية
| العنوان: |
Anti‐Oxidative and Anti‐Inflammatory Micelles: Break the Dry Eye Vicious Cycle. |
| المؤلفون: |
Li, Su, Lu, Zhouyu, Huang, Yue, Wang, Yin, Jin, Qiao, Shentu, Xingchao, Ye, Juan, Ji, Jian, Yao, Ke, Han, Haijie |
| المصدر: |
Advanced Science; 6/13/2022, Vol. 9 Issue 17, p1-16, 16p |
| مصطلحات موضوعية: |
DRY eye syndromes, MICELLES, PHENOTYPIC plasticity, EYE drops, REACTIVE oxygen species |
| مستخلص: |
Dry eye disease (DED) impacts ≈30% of the world's population and causes serious ocular discomfort and even visual impairment. Inflammation is one core cause of the DED vicious cycle, a multifactorial deterioration in DED process. However, there are also reactive oxygen species (ROS) regulating inflammation and other points in the cycle from the upstream, leading to treatment failure of current therapies merely targeting inflammation. Accordingly, the authors develop micelle‐based eye drops (more specifically p38 mitogen‐activated protein kinases (MAPK) inhibitor Losmapimod (Los)‐loaded and ROS scavenger Tempo (Tem)‐conjugated cationic polypeptide micelles, designated as MTem/Los) for safe and efficient DED management. Cationic MTem/Los improve ocular retention of conjugated water‐soluble Tem and loaded water‐insoluble Los via electrostatic interaction with negatively charged mucin on the cornea, enabling an increase in therapeutic efficiency and a decrease in dosing frequency. Mechanistically, MTem/Los effectively decrease ROS over‐production, reduce the expression of proinflammatory cytokines and chemokines, restrain macrophage proinflammatory phenotypic transformation, and inhibit cell apoptosis. Therapeutically, the dual‐functional MTem/Los suppress the inflammatory response, reverse corneal epithelial defect, save goblet cell dysfunction, and recover tear secretion, thus breaking the vicious cycle and alleviating the DED. Moreover, MTem/Los exhibit excellent biocompatibility and tolerability for potential application as a simple and rapid treatment of oxidative stress‐ and inflammation‐induced disorders, including DED. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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