Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity
| العنوان: | Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity |
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| المؤلفون: | Reza Badalzadeh, Alireza Alihemmati, Goltaj Bayrami, Rana Keyhanmanesh, Mustafa Mohammadi, Pouran Karimi, Aniseh Javadi, Milad Zadi-Heydarabad |
| المصدر: | Advanced Pharmaceutical Bulletin Advanced Pharmaceutical Bulletin, Vol 8, Iss 2, Pp 319-329 (2018) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Mitochondrial ROS, Ischemia, Pharmaceutical Science, 030204 cardiovascular system & hematology, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Autophagy, Vildagliptin, General Pharmacology, Toxicology and Pharmaceutics, Cardioprotection, Ischemic postconditioning, business.industry, lcsh:RM1-950, Diabetes, medicine.disease, Streptozotocin, Reperfusion injury, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Mitochondrial function, business, Ligation, medicine.drug, Research Article |
| الوصف: | Purpose: Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Methods: Diabetes was established by high fat diet/low dose of streptozotocin and lasted for 12 weeks. The diabetic rats received Vilda (6 mg/kg/day, orally) for one month before I/R. Myocardial regional ischemia was induced through the ligation of left coronary artery, and IPostC was applied immediately at the onset of reperfusion. The infarct size was assessed by a computerised planimetry and left ventricles samples were harvested for cardiac mitochondrial function studies (ROS production, membrane potential and staining) and western blotting was used for determination of autophagy markers. Results: None of Vilda or IPostC but combination of them could significantly reduce the infarct size of diabetic hearts, comparing to control (P |
| اللغة: | English |
| تدمد: | 2251-7308 2228-5881 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7872bddb76c6c9b1c8b3348d556bc5Test http://europepmc.org/articles/PMC6046419Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb7872bddb76c6c9b1c8b3348d556bc5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22517308 22285881 |
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