دورية أكاديمية
Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity
| العنوان: | Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity |
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| المؤلفون: | Goltaj Bayrami, Alireza Alihemmati, Pouran Karimi, Aniseh Javadi, Rana Keyhanmanesh, Mustafa Mohammadi, Milad Zadi-Heydarabad, Reza Badalzadeh |
| المصدر: | Advanced Pharmaceutical Bulletin, Vol 8, Iss 2, Pp 319-329 (2018) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Ischemic postconditioning, Diabetes, Reperfusion injury, Autophagy, Mitochondrial function, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Purpose: Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Methods: Diabetes was established by high fat diet/low dose of streptozotocin and lasted for 12 weeks. The diabetic rats received Vilda (6 mg/kg/day, orally) for one month before I/R. Myocardial regional ischemia was induced through the ligation of left coronary artery, and IPostC was applied immediately at the onset of reperfusion. The infarct size was assessed by a computerised planimetry and left ventricles samples were harvested for cardiac mitochondrial function studies (ROS production, membrane potential and staining) and western blotting was used for determination of autophagy markers. Results: None of Vilda or IPostC but combination of them could significantly reduce the infarct size of diabetic hearts, comparing to control (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2228-5881 2251-7308 |
| العلاقة: | http://apb.tbzmed.ac.ir/PDF/apb-8-319.pdfTest; https://doaj.org/toc/2228-5881Test; https://doaj.org/toc/2251-7308Test |
| DOI: | 10.15171/apb.2018.037 |
| الوصول الحر: | https://doaj.org/article/7a2421dd2ab24f859f2915ac5abd3131Test |
| رقم الانضمام: | edsdoj.7a2421dd2ab24f859f2915ac5abd3131 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22285881 22517308 |
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| DOI: | 10.15171/apb.2018.037 |