التفاصيل البيبلوغرافية
| العنوان: |
The Role of the JAK-STAT Signaling Pathway in the Protective Effects of Hepatic Ischemia Post-conditioning Against the Injury Induced by Ischemia/Reperfusion in the Rat Liver. |
| المؤلفون: |
Ghasemi Pour Afshar, Neda, Arab, Hossein Ali, Vatannejad, Akram, Ashabi, Ghorbangol, Golabchifar, Ali akbar |
| المصدر: |
Advanced Pharmaceutical Bulletin; 2024, Vol. 14 Issue 1, p224-230, 7p |
| مصطلحات موضوعية: |
ASPARTATE aminotransferase, JAK-STAT pathway, REPERFUSION, ISCHEMIC postconditioning, ISCHEMIA, ALANINE aminotransferase |
| مستخلص: |
Purpose: Hepatic ischemic post-conditioning (IPOC) is shown to protect the liver from injury induced by ischemia/reperfusion (IR). However, the mechanism underlying this protection has remained elusive. The present study aimed to investigate the role of the interleukin 6-Janus kinase-signal transducers and activators of transcription (IL-6-JAK-STAT) pathway in the protective effect of hepatic IPOC against the IR-induced injury in the liver. Methods: Twenty-five rats were randomly divided into 5 groups of (1) sham-operated, (2) IR, (3) IR+hepatic IPOC, (4) IR+tofacitinib (TOFA), and (5) IR+TOFA+hepatic IPOC. The changes induced by IR and the effects of different treatments were assessed by enzyme release, histopathological observations, the serum level of IL-6, and the occurrence of apoptosis detected via the expression of the Bax/Bcl-2 ratio. Results: The hepatic IPOC improved the liver injury induced by IR as shown by histological changes, reduction of IL-6 level, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) compared to the IR group (P <0.001,> P <0.05,> P P<0.05).> Conclusion: It suggests that the protective effect of hepatic IPOC against IR-induced injury may be mediated by activating the IL-6-JAK-STAT pathway. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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