A Self‐Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type‐II ICD Inducer for Cancer Vaccines
| العنوان: | A Self‐Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type‐II ICD Inducer for Cancer Vaccines |
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| المؤلفون: | Xin Jin, Yunjiao Zhang, Meng Gao, Minjie Zhang, Ben Zhong Tang |
| المصدر: | Advanced Materials. 34:2205701 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aldehydes, Mechanics of Materials, Neoplasms, Mechanical Engineering, Humans, Antineoplastic Agents, Chlorambucil, Immunogenic Cell Death, General Materials Science, Cancer Vaccines |
| الوصف: | Immunogenic cell death (ICD) can activate the anticancer immune response and is highly attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic reticulum (ER) stress, and a series of ICD inducers has recently been reported based on ER-targeted photodynamic/photothermal agents or metal complexes. However, these ER-targeted ICD inducers suffer from complicated synthesis and heavy-metal cytotoxicity. Inspired by the promising clinical potential of small organic molecules, herein, an ER-targeted fluorescent self-reporting ICD inducer, SA-Cbl, is developed by simple conjugation of the chemotherapeutic drug chlorambucil (Cbl) with salicylaldehyde (SA). SA-Cbl can selectively accumulate in the ER to induce rapid ROS generation and an unfolded protein response process, which leads to a fast release of damage-associated molecular patterns and efficient dendritic cells maturation. Meanwhile, the ER-targeted accumulation and ER-stress-inducing process can be in situ monitored based on the turn-on fluorescence of SA-Cbl, which is highly pH- and polarity-sensitive and can selectively interact with ER proteins. Compared with the traditional chemotherapy drug doxorubicin, the superior anticancer immunity effect of SA-Cbl is verified via an in vivo tumor model. This study thus provides a new strategy for developing fluorescent self-reporting ICD inducers by decoration of chemotherapeutic drugs with pH and polarity-sensitive organic fluorophores. |
| تدمد: | 1521-4095 0935-9648 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fa88929e168fb779721b6e765fc312Test https://doi.org/10.1002/adma.202205701Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c5fa88929e168fb779721b6e765fc312 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214095 09359648 |
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