Synergistical Starvation and Chemo‐Dynamic Therapy for Combating Multidrug‐Resistant Bacteria and Accelerating Diabetic Wound Healing
| العنوان: | Synergistical Starvation and Chemo‐Dynamic Therapy for Combating Multidrug‐Resistant Bacteria and Accelerating Diabetic Wound Healing |
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| المؤلفون: | Yuanhong Xu, Danxia Li, Yanfang Zhang, Tao Chen, Haitao Niu |
| المصدر: | Advanced Healthcare Materials. 10:2100716 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.drug_class, Antibiotics, Biomedical Engineering, Pharmaceutical Science, Microbiology, Biomaterials, Mice, chemistry.chemical_compound, In vivo, Drug Resistance, Multiple, Bacterial, Diabetes Mellitus, medicine, Poor wound healing, Animals, Humans, Glucose oxidase, Metal-Organic Frameworks, Wound Healing, Bacteria, biology, Chemistry, biology.organism_classification, In vitro, Anti-Bacterial Agents, biology.protein, Gluconic acid, Cattle, Peroxidase |
| الوصف: | The application of the antibiotic drug has dramatically decreased the infection and promoted the development of surgery, but drug-resistant bacteria appeared along with the abuse of antibiotics. Especially, wound in diabetic patients provides more glucose for bacteria resulting in poor wound healing. Therefore, it is imminent to explore advanced agents for combating multidrug-resistant bacteria and accelerating diabetic wound healing. Herein, metal-organic frameworks based nanoreactors loaded with glucose oxidase (GOx) and peroxidase-like bovine hemoglobin (BHb) are designed to construct an effective cascaded catalytic antibacterial system. Therein, GOx can cost the glucose, and release H2 O2 simultaneously, which can then be transformed into hydroxyl radicals by BHb. As a result, the as-prepared nanoreactors can play the roles of both starving and killing toward the multidrug-resistant bacteria. Furthermore, the produced gluconic acid can reduce the pH of working condition, which is beneficial for both the enhancement of peroxidase activity and the inhibition of the bacteria growth. More importantly, the constructed nanoreactors can be degraded and excreted from the body in the form of feces, which render the as-proposed nanoreactors qualified as effective and safe materials for both combating multidrug-resistant bacteria in vitro and accelerating the diabetic wound healing in vivo of the mouse model. |
| تدمد: | 2192-2659 2192-2640 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d326e706940ea4b63f24ae0503b172Test https://doi.org/10.1002/adhm.202100716Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a9d326e706940ea4b63f24ae0503b172 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922659 21922640 |
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