Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
| العنوان: | Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion |
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| المؤلفون: | Tuomas P. J. Knowles, Corinna Schilling, Bernd Knöll, Stefanie Sieste, Francesco Simone Ruggeri, Christoph Meier, Christopher Meyer zu Reckendorf, Christopher V. Synatschke, Sean Harvey, David Y. W. Ng, Thomas Mack, Tanja Weil, Laura Pendi |
| المصدر: | Advanced Healthcare Materials Advanced Healthcare Materials 7 (2018) 11 Advanced Healthcare Materials, 7(11) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | neuronal growth, Fluorophore, Indoles, hybrid nanomaterial, Polymers, Growth Cones, Biomedical Engineering, Nanofibers, Pharmaceutical Science, Nanotechnology, 02 engineering and technology, peptide nanofibers, 010402 general chemistry, 01 natural sciences, Nanomaterials, Polymerization, Biomaterials, chemistry.chemical_compound, Mice, Nerve Fibers, Coated Materials, Biocompatible, Cell Adhesion, Animals, chemistry.chemical_classification, amyloid fibers, polydopamine coating, Adhesion, Polymer, 021001 nanoscience & nanotechnology, 3. Good health, 0104 chemical sciences, Supramolecular polymers, chemistry, Nanofiber, 0210 nano-technology, Peptides, Boronic acid |
| الوصف: | Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. The peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers, is demonstrated. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing functionalities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth, and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion. |
| وصف الملف: | application/pdf; text/html; application/octet-stream |
| اللغة: | English |
| تدمد: | 2192-2640 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea36263c7cc2bd57219e4a8f8cd0b819Test https://doi.org/10.1002/adhm.201701485Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea36263c7cc2bd57219e4a8f8cd0b819 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922640 |
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