المؤلفون: Bao, Shu-Juan, Li, Chang Ming, Zang, Jian-Feng, Cui, Xiao-Qiang, Qiao, Yan, Guo, Jun

المصدر: Advanced Functional Materials; Feb2008, Vol. 18 Issue 4, p591-599, 9p

المؤلفون: Bao, Shu‐Juan, Li, Chang Ming, Zang, Jian‐Feng, Cui, Xiao‐Qiang, Qiao, Yan, Guo, Jun

المصدر: Advanced Functional Materials; February 2008, Vol. 18 Issue: 4 p591-599, 9p

مستخلص: A new, slack, and uniformly porous TiO2material is synthesized by a simple, carbon nanotube (CNT) template‐assisted hydrothermal method and is further explored for protein immobilization and biosensing. Results demonstrate that the material has a large specific surface area and a unique nanostructure with a uniform pore‐size distribution. Glucose oxidase (GOD) immobilized on the material exhibits facile, direct electrochemistry and good electrocatalytic performance without any electron mediator. The fabricated glucose oxidase sensor shows good stability and high sensitivity, which indicates that the slack porous TiO2is an attractive material for use in the fabrication of biosensors, particularly enzymatic sensors, because of its direct electrochemistry, high specific surface area, and unique nanostructure for efficient immobilization of biomolecules.

المؤلفون: Wan, Yingpeng, Lu, Guihong, Zhang, Jinfeng, Wang, Ziying, Li, Xiaozhen, Chen, Rui, Cui, Xiao, Huang, Zhongming, Xiao, Yafang, Chelora, Jipsa, Zhang, Wenjun, Liu, Yanhong, Li, Min, Xie, Hai‐Yan, Lee, Chun‐Sing

المصدر: Advanced Functional Materials; 9/26/2019, Vol. 29 Issue 39, pN.PAG-N.PAG, 1p

مصطلحات موضوعية: FREE radicals, TUMORS

مستخلص: Free Radicals: A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy (Adv. Funct. In article number 1903436, Jinfeng Zhang, Chun-Sing Lee, and co-workers develop a biocompatible free radicals nanogenerator for efficient hypoxic tumor therapy. Biocompatibility, oxygen-independent free radicals, photothermal therapy, real-time monitoring, tumor hypoxia. [Extracted from the article]

: Copyright of Advanced Functional Materials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Wan, Yingpeng, Lu, Guihong, Zhang, Jinfeng, Wang, Ziying, Li, Xiaozhen, Chen, Rui, Cui, Xiao, Huang, Zhongming, Xiao, Yafang, Chelora, Jipsa, Zhang, Wenjun, Liu, Yanhong, Li, Min, Xie, Hai‐Yan, Lee, Chun‐Sing

المصدر: Advanced Functional Materials; 9/26/2019, Vol. 29 Issue 39, pN.PAG-N.PAG, 1p

مصطلحات موضوعية: REACTIVE oxygen species, PHOTOTHERMAL effect, DRUG monitoring, INDOCYANINE green, PHOTODYNAMIC therapy, GRANZYMES, FREE radicals

مستخلص: Hypoxic microenvironment severely reduces therapeutic efficacy of oxygen‐dependent photodynamic therapy in solid tumor due to the hampered cytotoxic oxygen radicals generation. Herein, a biocompatible nanoparticle (NP) is developed by combining bovine serum albumin, indocyanine green (ICG), and an oxygen‐independent radicals generator (AIPH) for efficient sequential cancer therapy, denoted as BIA NPs. Upon near‐infrared irradiation, the photothermal effect generated by ICG will induce rapid decomposition of AIPH to release cytotoxic alkyl radicals, leading to cancer cell death in both normoxic and hypoxic environments. Moreover, such nanosystem provides the highest AIPH loading capacity (14.9%) among all previously reported radical nanogenerators (generally from 5–8%). Additionally, the aggregation‐quenched fluorescence of ICG molecules in the NPs can be gradually released and recovered upon irradiation enabling real‐time drug release monitoring. More attractively, these BIA NPs exhibit remarkable anticancer effects both in vitro and in vivo, achieving 100% tumor elimination and 100% survival rate among 50 days treatment. These results highlight that this albumin‐based nanoplatform is promising for high‐performance cancer therapy circumventing hypoxic tumor environment and possessing great potential for future clinical translation. [ABSTRACT FROM AUTHOR]

: Copyright of Advanced Functional Materials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)