التفاصيل البيبلوغرافية
| العنوان: |
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack. |
| المؤلفون: |
Guha, Abhishek1 (AUTHOR), Waris, Saboora1,2 (AUTHOR), Nabors, Louis B.1 (AUTHOR), Filippova, Natalia1 (AUTHOR), Gorospe, Myriam3 (AUTHOR), Kwan, Thaddaeus1 (AUTHOR), King, Peter H.1,4,5 (AUTHOR) phking@uabmc.edu |
| المصدر: |
Advanced Drug Delivery Reviews. Feb2022, Vol. 181, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*GLIOBLASTOMA multiforme, *BRAIN tumors, *RNA regulation, *SMALL molecules, *STEM cells |
| مستخلص: |
[Display omitted] Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of ∼15 months. Resistance to treatment arises from the extensive cellular and molecular heterogeneity in the three major components: glioma tumor cells, glioma stem cells, and tumor-associated microglia and macrophages. Within this triad, there is a complex network of intrinsic and secreted factors that promote classic hallmarks of cancer, including angiogenesis, resistance to cell death, proliferation, and immune evasion. A regulatory node connecting these diverse pathways is at the posttranscriptional level as mRNAs encoding many of the key drivers contain adenine- and uridine rich elements (ARE) in the 3′ untranslated region. Human antigen R (HuR) binds to ARE-bearing mRNAs and is a major positive regulator at this level. This review focuses on basic concepts of ARE-mediated RNA regulation and how targeting HuR with small molecule inhibitors represents a plausible strategy for a multi-pronged therapeutic attack on GBM. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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