دورية أكاديمية
Perylene-Mediated Cytoskeletal Dysfunction Remodels Cancer-Associated Fibroblasts to Augment Antitumor Immunotherapy.
| العنوان: | Perylene-Mediated Cytoskeletal Dysfunction Remodels Cancer-Associated Fibroblasts to Augment Antitumor Immunotherapy. |
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| المؤلفون: | Shi, Bing, Lou, Xue, Ma, Feiyan, Nie, Yanling, Chen, Haoxing, Huang, Yongwei, Zhang, Wei, Wang, Tie |
| المصدر: | Adv Healthc Mater ; ISSN:2192-2659 ; Volume:13 ; Issue:11 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | cancer‐associated fibroblasts, cytoskeletal dysfunction, immunotherapy, perylene, reactive oxygen species (ROS) |
| الوصف: | Targeted reprogramming of cancer-associated fibroblasts (CAFs) is one of the most essential cancer therapies. However, how to reprogram active CAFs toward deactivated state still remains immense challenge. To tackle this challenge, herein, one perylene N, N'-bis(2-((dimethylammonium)ethylene)-2-(methoxylethyl))-1, 6, 7, 12-tetrachloroperylene-3, 4, 9, 10-tetracarboxylic diimide (PDIC-OC) is prepared, which can trigger endogenous reactive oxygen species (ROS) burst to result in cytoskeletal dysfunction and cell apoptosis so that suppress transforming growth factor β (TGF-β) production. As a result, PDIC-OC can reprogram the activated CAFs and relieve immunosuppressive tumor microenvironment by efficient polarization of M2-typed macrophages into M1-typed ones, downregulation of alpha-smooth muscle actin (α-SMA), alleviation of hypoxic state to promote infiltration of cytotoxic T lymphocytes, and ultimately realizes outstanding antitumor performance on B16F10 tumor-xenografted and lung-metastatic mouse model even at low concentration of 1 mg kg-1 body weight. This work thus presents a novel strategy that cytoskeleton dysfunction and cell apoptosis cooperatively suppress the secretion of TGF-β to reprogram CAFs and meanwhile clarifies intrinsic mechanism for perylene-triggered chemo-immunotherapy against hypoxic tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1002/adhm.202303837Test; https://pubmed.ncbi.nlm.nih.gov/38183408Test |
| DOI: | 10.1002/adhm.202303837 |
| الإتاحة: | https://doi.org/10.1002/adhm.202303837Test https://pubmed.ncbi.nlm.nih.gov/38183408Test |
| حقوق: | © 2024 Wiley‐VCH GmbH. |
| رقم الانضمام: | edsbas.1C3A33E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/adhm.202303837 |
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