دورية أكاديمية
Integrating long-acting injectable treatment to improve medication adherence among persons living with HIV and opioid use disorder: study protocol
| العنوان: | Integrating long-acting injectable treatment to improve medication adherence among persons living with HIV and opioid use disorder: study protocol |
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| المؤلفون: | Kirsten J. Langdon, Anthony E. Hitch, Alexandra B. Collins, Curt G. Beckwith, Sara Becker, Karen Tashima, Josiah D. Rich |
| المصدر: | Addiction Science & Clinical Practice, Vol 18, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Social pathology. Social and public welfare. Criminology |
| مصطلحات موضوعية: | Opioid use disorder, HIV, Medications for opioid use disorder, Long-acting injectable medication, Antiretroviral therapy, Antiviral resistance, Medicine (General), R5-920, Social pathology. Social and public welfare. Criminology, HV1-9960 |
| الوصف: | Abstract Background Oral antiretroviral therapy (ART) has been effective at reducing mortality rates of people with HIV. However, despite its effectiveness, people who use drugs face barriers to maintaining ART adherence. Receipt of opioid agonist treatment, in the context of HIV care, is associated with medication adherence and decreased HIV viral loads. Recent pharmacological advancements have led to the development of novel long-acting, injectable, medications for both HIV (cabotegravir co-administered with rilpivirine) and OUD (extended-release buprenorphine). These therapies have the potential to dramatically improve adherence by eliminating the need for daily pill-taking. Despite the extensive evidence base supporting long-acting injectable medications for both HIV and OUD, and clinical guidelines supporting integrated care provision, currently little is known about how these medications may be optimally delivered to this population. This paper presents the study design for the development of a clinical protocol to guide the delivery of combined treatment for HIV and OUD using long-acting injectable medications. Methods The study aims are to: (1) develop a clinical protocol to guide the delivery of combined LAI for HIV and OUD by conducting in-depth interviews with prospective patients, clinical content experts, and other key stakeholders; and (2) conduct This single group, open pilot trial protocol to assess feasibility, acceptability, and safety among patients diagnosed with HIV and OUD. Throughout all phases of the study, information on patient-, provider-, and organizational-level variables will be collected to inform future implementation. Discussion Findings from this study will inform the development of a future study to conduct a fully-powered Hybrid Type 1 Effectiveness-Implementation design. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1940-0640 |
| العلاقة: | https://doaj.org/toc/1940-0640Test |
| DOI: | 10.1186/s13722-023-00418-6 |
| الوصول الحر: | https://doaj.org/article/547fdfd000b341b39d2fcc0fe7ed24eaTest |
| رقم الانضمام: | edsdoj.547fdfd000b341b39d2fcc0fe7ed24ea |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19400640 |
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| DOI: | 10.1186/s13722-023-00418-6 |