Tailored dose baclofen in patients with alcoholic liver disease: A case series with 2-year follow-up of hospitalisation
| العنوان: | Tailored dose baclofen in patients with alcoholic liver disease: A case series with 2-year follow-up of hospitalisation |
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| المؤلفون: | James Lewsey, Jonathan Chick, Benn Macdonald, M. Heydtmann, Neil Masson, Jan Cosgrave, Aleksandra Irnazarow, Leona Cunningham, Amanda Nardone |
| المصدر: | Addiction Research & Theory. 23:510-517 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Alcoholic liver disease, medicine.medical_specialty, Alcohol addiction, business.industry, Medicine (miscellaneous), medicine.disease, Surgery, chemistry.chemical_compound, Liver disease, Baclofen, chemistry, Tolerability, Internal medicine, medicine, In patient, Health board, business, Alcohol consumption |
| الوصف: | Introduction: Alcohol addiction is a major health burden with its consequences including liver disease and frequent hospitalisations. We used tailored-dose baclofen in patients with alcoholic liver disease and investigated hospital re-admissions before and after baclofen dose was initiated as well as tolerability and patient-reported alcohol consumption. Methods: Fifty-three hospitalised patients with alcoholic liver disease started tailored dose baclofen (median: 5.05 months, median highest dose before tapering down: 60 mg). Patients were followed-up for hospitalisation data from the health board database (mean hospitalisation follow up: 31 months) and patients were sent standardized questionnaires. Results: Baclofen was generally well tolerated with dose reductions in four patients. In the 2 years after initiation of the treatment, patients spent on an average of 19.1 d in the hospital per year compared to 25.48 d before the treatment initiation (p = 0.59). Respondents (19 patients) reported a r... |
| تدمد: | 1476-7392 1606-6359 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::42d91ea812768c4c21fc0c5823e6c6ecTest https://doi.org/10.3109/16066359.2015.1040003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........42d91ea812768c4c21fc0c5823e6c6ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14767392 16066359 |
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