Cognitive function assessment in elderly patients with overactive bladder treated with transdermal oxybutynin
| العنوان: | Cognitive function assessment in elderly patients with overactive bladder treated with transdermal oxybutynin |
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| المؤلفون: | M. Leva Vallejo, Salvador Arlandis-Guzman, G. Morales Solchaga, C. Zubiaur Líbano, Carlos Müller-Arteaga, O. Gonzalez Garcia, R. El Khoury Moreno, J.E. Batista-Miranda, Carlos Errando-Smet, J. Casas Nebra |
| المصدر: | ACTAS UROLOGICAS ESPANOLAS r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Urinary urgency, Transdermal patch, Treatment adherence, 030232 urology & nephrology, Muscarinic Antagonists, urologic and male genital diseases, Administration, Cutaneous, 03 medical and health sciences, Aging, Cognitive impairment, Deterioro cognitivo, Envejecimiento, Overactive bladder, Oxibutinina, Oxybutynin, Parche transdérmico, Transdermalpatch, Vejiga hiperactiva, Cognition, 0302 clinical medicine, Internal medicine, Humans, Medicine, Cognitive impairment, Oxybutynin, Aged, Retrospective Studies, Transdermal, Aged, 80 and over, Psychological Tests, Urinary Bladder, Overactive, business.industry, General Medicine, medicine.disease, Overactive bladder, Mandelic Acids, Female, medicine.symptom, business, medicine.drug |
| الوصف: | Older patients with overactive bladder under antimuscarinic treatment are especially susceptible to cognitive impairment. The aim was to assess short term changes in cognitive function in elderly patients with overactive bladder treated with transdermal oxybutynin.Observational, retrospective, multicentre study in patients with overactive bladder aged 65-80 years undergoing treatment with transdermal oxybutynin. Before and after one month of treatment, cognitive function using the Memory Alteration Test and Clock-Drawing Test, changes in symptoms with validated questionnaires, patient perception of treatment response using Treatment Benefit Scale and treatment adherence with the modified Morisky-Green test, were assessed.From 85 eligible patients, 70 completed the assessment (mean age: 71.4±4.5; BMI: 28.7±3.1kg/m2). No cognitive impairment was observed after one month with transdermal oxybutynin: Memory Alteration Test (+1 point; 95%CI: 0.0-1.5), Clock-Drawing Test (0 points; 95%CI: 0.0-0.0). A statistically significant improvement (P.001) was observed in all urinary storage symptoms, except stress urinary incontinence. There was an improvement in the Bladder Control Self-Assessment Questionnaire (symptom score: -2.27; 95%CI: -2.8, -1.7; P.001; bother score: -2.73; 95%CI: -3.3, -2.1; P.001). 70% of patients reported either a stable or improved bladder condition according to the Patient Perception of Bladder Condition questionnaire. 72.8% of patients reported that their urinary problems had improved or greatly improved with an 84.3% treatment adherence.No cognitive impairment was observed in elderly patients after one month of treatment with transdermal oxybutynin; urinary urgency symptoms improved and there was adequate treatment adherence. |
| تدمد: | 2173-5786 0210-4806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0f057900bb1ce6523671f8b7aff54bTest https://doi.org/10.1016/j.acuroe.2019.02.004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9f0f057900bb1ce6523671f8b7aff54b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21735786 02104806 |
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