دورية
Leptin and thermogenesis in humans
| العنوان: | Leptin and thermogenesis in humans |
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| المؤلفون: | TUOMINEN, J. A., EBELING, P., HEIMAN, M. L., STEPHENS, T., KOIVISTO, V. A. |
| المصدر: | Acta Physiologica Scandinavica; April 1997, Vol. 160 Issue: 1 p83-87, 5p |
| مستخلص: | We examined changes in serum leptin concentrations and thermogenesis in 12 healthy men (39 ± 2 years, BMI 22.8 ± 0.3 kg m−2) during a 4 h euglycaemic hyperinsulinaemia performed on a control day and after a day of a competitive marathon run. As compared with the control day, after the marathon, baseline FFA concentration (543 ± 0.73 vs. 955 ± 96 μmol L−1, P < 0.05), lipid oxidation rate (0.8 ± 0.1 vs. 1.2 ± 0.1 mg kg−1min−1}, P < 0.01) and energy expenditure (5.2 ± 0.1 vs. 5.5 ± 0.1 kJ min−1}, P < 0.01) were elevated. Baseline serum leptin concentrations were similar on the control and postexercise days and increased during insulin infusion by 35–45% on both days (P ≤ 0.01). Baseline serum leptin concentration correlated directly with serum insulin ( r = 0.65, P < 0.05) and cortisol ( r = 0.64, P < 0.05), and inversely with serum growth hormone concentration ( r = −0.66, P < 0.05). In the postexercise study, the rise in energy expenditure during insulin clamp correlated with serum leptin concentration as determined before ( r= 0.61, P < 0.05) or at the end of insulin infusion ( r = 0.55, P < 0.05). Thus, in healthy individuals with normal body weight: (1) hyperinsulinaemia increases serum leptin concentrations; (2) a rise in energy expenditure correlates with serum leptin concentration. These data suggest that leptin is involved in the regulation of energy expenditure in humans. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00016772 1365201X |
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| DOI: | 10.1046/j.1365-201X.1997.00102.x |