Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits1
| العنوان: | Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits1 |
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| المؤلفون: | Hong-mei Zhao, Na Li, Zhian Hu, Song-tao Li, Jie Yan, Xiaowei Chen |
| المصدر: | Acta Pharmacologica Sinica. 27:212-216 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, business.industry, digestive, oral, and skin physiology, General Medicine, Peripheral, Atropine, Endocrinology, nervous system, Internal medicine, mental disorders, Sphincter of Oddi, medicine, Excitatory postsynaptic potential, Cholinergic, Pharmacology (medical), Local injection, business, Spike potential, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, medicine.drug |
| الوصف: | Aim: To investigate the effects of peripheral orexins on myoelectric activity of the sphincter of Oddi (SO) in fasted rabbits, and carry out a preliminary investigation into the mechanisms underlying these effects. Methods: Myoelectric activity of SO in fasted rabbits was recorded before and after intravenous or local application of orexins. The effects of intravenous atropine on orexin-increased myoelectric activity of SO were tested. Results: Myoelectric activity of SO was activated by both intravenous and local injection of orexin-A or orexin-B. Intravenous application of atropine completely inhibited the excitatory effect of orexins on SO. Conclusion: Peripheral application of orexins can increase myoelectric activity of SO in fasted rabbits, which is partially associated with the activation of the cholinergic pathway. |
| تدمد: | 1745-7254 1671-4083 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4487b6c376a470c0321b15d0f698ba3cTest https://doi.org/10.1111/j.1745-7254.2006.00266.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........4487b6c376a470c0321b15d0f698ba3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17457254 16714083 |
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