Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy
| العنوان: | Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy |
|---|---|
| المؤلفون: | Lihong Wang, Haihai Liang, Yongting Zhao, Jinjing Wei, Weijie Du |
| المصدر: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 1-17 (2022) |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cell death, Programmed cell death, Entosis, Necroptosis, Cardiomyopathy, Apoptosis, RM1-950, Review, Diabetic cardiomyopathy, Diabetes mellitus, Pyroptosis, Ferroptosis, Medicine, cardiovascular diseases, General Pharmacology, Toxicology and Pharmaceutics, Aautosis, business.industry, Autophagy, musculoskeletal system, medicine.disease, Autophagic cell death, cardiovascular system, Cancer research, Therapeutics. Pharmacology, business |
| الوصف: | Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications (DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy (DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure. Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis, necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease. Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly, published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies. Graphical abstract This review article provides the research evidence for the presence and role of various types of cell death in diabetic cardiomyopathy, as well as the perspectives of future studies.Image 1 |
| تدمد: | 2211-3835 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a32142bc2712e40985780b2f252653Test https://doi.org/10.1016/j.apsb.2021.08.026Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d8a32142bc2712e40985780b2f252653 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113835 |
|---|