CONGENITAL HYPERPARATHYROIDISM AND VITAMIN D DEFICIENCY SECONDARY TO MATERNAL HYPOPARATHYROIDISM
| العنوان: | CONGENITAL HYPERPARATHYROIDISM AND VITAMIN D DEFICIENCY SECONDARY TO MATERNAL HYPOPARATHYROIDISM |
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| المؤلفون: | M. C. Chapuy, A Frederich, L Sann, René Francois, A. Thomas, L David |
| المصدر: | Acta Paediatrica. 65:381-385 |
| بيانات النشر: | Wiley, 1976. |
| سنة النشر: | 1976 |
| مصطلحات موضوعية: | Male, Vitamin, medicine.medical_specialty, Hypoparathyroidism, vitamin D deficiency, chemistry.chemical_compound, Pregnancy, Internal medicine, Immunoreactive parathormone, Cyclic AMP, medicine, Vitamin D and neurology, Humans, Vitamin D, Hyperparathyroidism, Hydroxycholecalciferols, business.industry, Infant, Newborn, Phosphorus, General Medicine, Vitamin D Deficiency, medicine.disease, Skeleton (computer programming), Pregnancy Complications, Hydroxyproline, Endocrinology, chemistry, Parathyroid Hormone, Bone lesion, Pediatrics, Perinatology and Child Health, Calcium, Female, business |
| الوصف: | A new case of congenital hyperparathyroidism secondary to maternal hypoparathyroidism is described. Neonatal roentgenograms of the skeleton showed severe bone demineralisation and the distal metaphyses of the long bones were spread, frayed and cupped. Elevated levels of serum immunoreactive parathormone (iPTH) were found at the age of 41 days=270 mulEq/ml (Normal: less than 50 mulEq/ml). A very low plasma 25-OH-D concentration (less than 4 ng/ml) was found at the same time in spite of previous administration of 600 units of vitamin D every day for 18 days and in spite of healing of the bone lesions. At the age of 3 months, 15 mg of vitamin D was given orally: iPTH levels which remained high 3 weeks before (210 mulEq/ml) were found to be normal one week after this vitamin D load (37 mulEq/ml). It is suggested that in congenital hyperparathyroidism secondary to maternal hypoparathyroidism, hyperparathyroidism increases the infants needs for vitamin D. This could result in a state of vitamin D deficiency which in turn would maintain the parathyroid hyperactivity. |
| تدمد: | 1651-2227 0803-5253 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad78527d6ed763591f1fa3f95fcfd523Test https://doi.org/10.1111/j.1651-2227.1976.tb04901.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ad78527d6ed763591f1fa3f95fcfd523 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16512227 08035253 |
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