التفاصيل البيبلوغرافية
| العنوان: |
Health-related quality of life in rectal cancer patients undergoing neoadjuvant chemoradiation with delayed surgery versus short-course radiotherapy with immediate surgery: a propensity score-matched cohort study. |
| المؤلفون: |
Couwenberg, Alice M., Burbach, Johannes P. M., Intven, Martijn P. W., Consten, Esther C. J., Schiphorst, Anandi H. W., Smits, Anke B., Wijffels, Niels A. T., Heikens, Joost T., Koopman, Miriam, van Grevenstein, Wilhemina M. U., Verkooijen, Helena M. |
| المصدر: |
Acta Oncologica; Apr2019, Vol. 58 Issue 4, p407-416, 10p, 1 Diagram, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
RECTUM tumors, COMBINED modality therapy, CONFIDENCE intervals, DIGESTIVE organ surgery, LONGITUDINAL method, QUALITY of life, QUESTIONNAIRES, LOGISTIC regression analysis, TREATMENT effectiveness, DESCRIPTIVE statistics, ODDS ratio, CHEMORADIOTHERAPY, EVALUATION, TUMOR treatment |
| مستخلص: |
Background: Neoadjuvant chemoradiation with delayed surgery (CRT-DS) and short-course radiotherapy with immediate surgery (SCRT-IS) are two commonly used treatment strategies for rectal cancer. However, the optimal treatment strategy for patients with intermediate-risk rectal cancer remains a discussion. This study compares quality of life (QOL) between SCRT-IS and CRT-DS from diagnosis until 24 months after treatment. Methods: In a prospective colorectal cancer cohort, rectal cancer patients with clinical stage T2-3N0-2M0 undergoing SCRT-IS or CRT-DS between 2013 and 2017 were identified. QOL was assessed using EORTC-C30 and EORTC-CR29 questionnaires before the start of neoadjuvant treatment (baseline) and at 3, 6, 12, 18 and 24 months after. Patients were 1:1 matched using propensity sore matching. Between- and within-group differences in QOL domains were analyzed with linear mixed-effects models. Symptoms and sexual interest at 12 and 24 months were compared using logistic regression models. Results: 156 of 225 patients (69%) remained after matching. The CRT-DS group reported poorer emotional functioning at 3, 6, 12, 18 and 24 months (mean difference with SCRT-IS: −9.4, −12.1, −7.3, −8.0 and −7.9 respectively), and poorer global health, physical-, role-, social- and cognitive functioning at 6 months (mean difference with SCRT-IS: −9.1, −9.8, −14.0, −9.2 and −12.6, respectively). Besides emotional functioning, all QOL domains were comparable at 12, 18 and 24 months. Within-group changes showed a significant improvement of emotional functioning after baseline in the SCRT-IS group, whereas only a minor improvement was observed in the CRT-DS group. Symptoms and sexual interest in male patients at 12 and 24 months were comparable between the groups. Conclusions: In rectal cancer patients, CRT-DS may induce a stronger decline in short-term QOL than SCRT-IS. From 12 months onwards, QOL domains, symptoms and sexual interest in male patients were comparable between the groups. However, emotional functioning remained higher after SCRT-IS than after CRT-DS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
