Distribution patterns of tau pathology in progressive supranuclear palsy
| العنوان: | Distribution patterns of tau pathology in progressive supranuclear palsy |
|---|---|
| المؤلفون: | Gabor G. Kovacs, Edward B. Lee, Ellen Gelpi, Corey T. McMillan, Claire Troakes, David G. Coughlin, Sharon X. Xie, John Q. Trojanowski, Carolin Kurz, Günter U. Höglinger, Gesine Respondek, Armin Giese, Murray Grossman, David J. Irwin, Yaroslau Compta, Thomas Arzberger, Laura Donker Laat, Virginia M.-Y. Lee, John L. Robinson, Safa Al-Sarraj, Milica Ječmenica Lukić, John C. van Swieten, Sigrun Roeber |
| المساهمون: | Neurology, Clinical Genetics |
| المصدر: | Acta neuropathologica, vol 140, iss 2 Acta Neuropathologica Acta neuropathologica 140(2), 99-119 (2020). doi:10.1007/s00401-020-02158-2 Kovacs, G G, Lukic, M J, Irwin, D J, Arzberger, T, Respondek, G, Lee, E B, Coughlin, D, Giese, A, Grossman, M, Kurz, C, McMillan, C T, Gelpi, E, Compta, Y, van Swieten, J C, Laat, L D, Troakes, C, Al-Sarraj, S, Robinson, J L, Roeber, S, Xie, S X, Lee, V M Y, Trojanowski, J Q & Höglinger, G U 2020, ' Distribution patterns of tau pathology in progressive supranuclear palsy ', Acta Neuropathologica, vol. 140, no. 2, pp. 99-119 . https://doi.org/10.1007/s00401-020-02158-2Test Acta Neuropathologica, 140(2), 99-119. Springer-Verlag |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Stage, Cerebellum, Aging, Striatum, Neurodegenerative, Alzheimer's Disease, Neurofibrillary tangle, Cohort Studies, Tufted astrocyte, pathology [Brain], Supranuclear Palsy, Propagation, Richardson syndrome, Brain, Middle Aged, analysis [tau Proteins], ddc, Subthalamic nucleus, Tauopathy, Frontotemporal Dementia (FTD), Globus pallidus, medicine.anatomical_structure, Neurological, Female, Supranuclear Palsy, Progressive, pathology [Supranuclear Palsy, Progressive], 1.1 Normal biological development and functioning, Clinical Sciences, tau Proteins, Biology, Pathology and Forensic Medicine, Progressive supranuclear palsy, Cellular and Molecular Neuroscience, Rare Diseases, Progressive, Underpinning research, medicine, Acquired Cognitive Impairment, Humans, ddc:610, Aged, Original Paper, Neurology & Neurosurgery, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Sequential involvement, medicine.disease, Coiled body, Brain Disorders, Dentate nucleus, Dementia, Neurology (clinical), Tau, Neuroscience |
| الوصف: | Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PSP pathology. We evaluated heat maps and distribution patterns of neuronal, astroglial, and oligodendroglial tau pathologies and their combinations in different clinical subtypes of PSP in postmortem brains. We used conditional probability and logistic regression to model the sequential distribution of tau pathologies across different brain regions. Tau pathology uniformly predominates in the neurons of the pallido-nigro-luysian axis in different clinical subtypes. However, clinical subtypes are distinguished not only by total tau load but rather cell-type (neuronal versus glial) specific vulnerability patterns of brain regions suggesting distinct dynamics or circuit-specific segregation of propagation of tau pathologies. For Richardson syndrome (n = 81) we recognize six sequential steps of involvement of brain regions by the combination of cellular tau pathologies. This is translated to six stages for the practical neuropathological diagnosis by the evaluation of the subthalamic nucleus, globus pallidus, striatum, cerebellum with dentate nucleus, and frontal and occipital cortices. This system can be applied to further clinical subtypes by emphasizing whether they show caudal (cerebellum/dentate nucleus) or rostral (cortical) predominant, or both types of pattern. Defining cell-specific stages of tau pathology helps to identify preclinical or early-stage cases for the better understanding of early pathogenic events, has implications for understanding the clinical subtype-specific dynamics of disease-propagation, and informs tau-neuroimaging on distribution patterns. Electronic supplementary material The online version of this article (10.1007/s00401-020-02158-2) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0001-6322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc72025191a7cb50eb9478ae655f1bbTest https://doi.org/10.1007/s00401-020-02158-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....abc72025191a7cb50eb9478ae655f1bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00016322 |
|---|