Epilepsies associated with focal cortical dysplasias (FCDs)
| العنوان: | Epilepsies associated with focal cortical dysplasias (FCDs) |
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| المؤلفون: | Harvey B. Sarnat, Giorgio Lo Russo, Imad Najm, Hans Holthausen, Laura Tassi |
| المصدر: | Acta Neuropathologica. 128:5-19 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Functional observations, Pathology, medicine.medical_specialty, Epilepsy, business.industry, Extramural, Brain, medicine.disease, Pathology and Forensic Medicine, Craniofacial Abnormalities, Malformations of Cortical Development, Cellular and Molecular Neuroscience, medicine, Animals, Humans, In patient, Epilepsy surgery, Epilepsies, Partial, Neurology (clinical), business |
| الوصف: | Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the international consensus classification of FCDs in light of more recently reported clinical, electrical, imaging and functional observations, and will also address areas of ongoing debate. In addition, we will summarize our current knowledge on pathobiology and epileptogenicity of FCDs as well as its underlying molecular and cellular mechanisms. The clinical (electroencephalographic, imaging, and functional) characteristics of major FCD subtypes and their implications on the presurgical evaluation and surgical management will be discussed in light of studies describing these characteristics and postoperative seizure outcomes in patients with medically intractable focal epilepsy due to histopathologically confirmed FCDs. |
| تدمد: | 1432-0533 0001-6322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec869d33bb0f59017a29935c5a2fecTest https://doi.org/10.1007/s00401-014-1304-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3dec869d33bb0f59017a29935c5a2fec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320533 00016322 |
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