التفاصيل البيبلوغرافية
| العنوان: |
FETAL FIBRONECTIN AND PHOSPHORILATED INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1 AS PREDICTORS OF SPONTANEUS PRETERM DELIVERY. |
| العنوان البديل: |
FETALNI FIBRONEKTIN I FOSFORILOVANI INSULINU SLIČAN FAKTOR RASTA-PROTEIN 1 KAO PREDIKTORI SPONTANOG PREVREMENOG POROĐAJA. |
| المؤلفون: |
Hadži-Lega, Marija1 marijahadzilega@yahoo.com, Daneva Markova, Ana1, Stefanović, Milan2, Girevski, Vlatko1 |
| المصدر: |
Acta Medica Medianae. Sep2014, Vol. 53 Issue 3, p11-18. 8p. 2 Charts, 4 Graphs. |
| مصطلحات موضوعية: |
*FIBRONECTINS, *SOMATOMEDIN, *CARRIER proteins, *PREMATURE labor, *PREGNANCY, *MANAGEMENT |
| الملخص (بالإنجليزية): |
The aim of the paper was to assess the combined use of cervical length, fetal fibronectin and cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in the prediction of preterm delivery in symptomatic women in the following 14 days. Cervical length was prospectively measured in 58 consecutive singleton pregnancies with intact membranes and regular contractions at 24-36 weeks; fetal fibronectin and phIGFBP-1 were also assessed. Demographic data was evaluated (history of previous preterm delivery, history of spontaneous abortion, parity, BMI, maternal age, Islamic or Orthodox religion). Values of all variables were evaluated (demographic data, cervical length and values of phIGFBP1 and fetal fibronectin) alone and in combination with cervical length of ≤ 15mm and more than 15 mm. PhIGFPB was positive in 30 patients (22 of them gave birth in 14 days). In women with cervical length less than 15 mm phIGFBP-1, it was positive in 9 pregnant women who were delivered in 14 days. In women with cervical length less than 25 mm phIGFBP-1 was positive in 26 patients (2 of them gave birth in 14 days). In patients with cervical length more than 25 mm phIGFBP-1 was positive in 4 patients (2 of them gave birth in 14 days). Using logistic regression we confirmed that with OR 0.117 and CI 95% (0.046-0.295) and p<0.01 odds for preterm birth among patients with negative test results, phIGFBP-1 was by 0.117 lower than the odds for preterm birth among patients with positive test results. Using the same test, we confirmed that with OR=14,722 (CI 95% 5.27-41.1), (p<0.01) cervical length less than 25 mm was a good predictor of preterm delivery in symptomatic patients. Probability for delivery in the following 14 days in patients with positive phIGFBP-1 and cervical length=15 mm is 0.88 or probability for not delivering in those patients is 0.12. Eighty-eight percents of patients with positive phIGFBP-1 and cervical length ≤15 mm will give birth in the following 14 days. In symptomatic women phIGFBP-1 may significantly improve the risk assessment for preterm delivery with cervical length and help to plan subsequent pregnancy management. [ABSTRACT FROM AUTHOR] |
| Abstract (Bosnian): |
Cilj rada bio je da se proceni kako kombinacija dužine cerviksa, fetalnog fibronektina i cervikalnog fosforilovanog insulinu sličnog faktora rasta–protein 1 (phIGFBP-1) utiče na predviđanje prevremenog porođaja kod simptomatskih trudnica u roku od 14 dana. Dužina cerviksa je prospektivno merena kod 58 jednoplodnih trudnoća, sa očuvanim membranama i regularnim kontrakcijama u periodu od 24. do 36. gestacijske nedelje; takođe su procenjivani i fetalni fibronektin i phIGFBP-1. Analizirani su i demografski podaci: istorija prethodnih prevremenih porođaja, istorija spontanog abortusa, paritet, BMI, starost majke, verska pripadnost – pravoslavna ili muslimanska. Vrednosti svih varijabli bile su procenjene (demografski podaci, dužina cerviksa, kao i vrednosti phIGFBP-1 i fetalnog fibronektina) pojedinačno i u kombinaciji sa dužinom cerviksa ≤ 15 mm i iznad 15 mm. Vrednost PhIGFPB bila je pozitivna kod 30 trudnica (22 trudnice su se porodile u narednih 14 dana). Kod trudnica sa dužinom cerviksa manjom od 15 mm, vrednost phIGFBP-1 bila je pozitivna kod 9 trudnica koje su se porodile u roku od 14 dana. Kod trudnica sa dužinom cerviksa > 25 mm, vrednost phIGFBP-1 je bila pozitivna kod četiri trudnice (dve trudnice su se porodile u narednih 14 dana). Primenom logističke regresije potvrđeno je da je sa vrednostima OR 0.117 i CI 95% (0.046-0.295) i p<0.01 za prevremene trudnoće kod trudnica sa negativnim rezultatima testa vrednost phIGFBP-1 bila za 0.117 niža u poređenju sa izgledima za prevremeni porođaj kod trudnica sa pozitivnim rezultatima testa. Primenom istog testa potvrđeno je da je sa vrednostima OR=14,722 i CI 95% (5,27-41.104) i p=0.009 (p<0.01) cervikalna dužina ispod 25 mm bila dobar prediktor prevremenog porođaja kod simptomatskih trudnica. Verovatnoća za porođaj u narednih 14 dana kod trudnica sa pozitivnom vrednošću phIGFBP-1 i dužinom cerviksa ≤15 mm iznosila je 0 .88, odnosno 0.12 da se porođaj ne desi. Pozitivna vrednost phIGFBP-1 i dužina cerviksa ≤15 mm odredila je porođaj u roku od 14 dana kod 88% ispitanica. Kod simptomatskih trudnica phIGFBP-1 može značajno da poboljša procenu rizika za prevremeni porođaj sa podatkom o dužini cerviksa i da pomogne u planiranju daljeg toka trudnoće. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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