دورية أكاديمية
TEŠKA TROMBOCITOPENIJA IZAZVANA VANKOMICINOM KOD 53-GODIŠNJE ŽENE ; SEVERE VANCOMYCIN-INDUCED THROMBOCYTOPENIA IN A 53-YEAR-OLD WOMAN
| العنوان: | TEŠKA TROMBOCITOPENIJA IZAZVANA VANKOMICINOM KOD 53-GODIŠNJE ŽENE ; SEVERE VANCOMYCIN-INDUCED THROMBOCYTOPENIA IN A 53-YEAR-OLD WOMAN |
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| المؤلفون: | ZDENČAR, DALIBOR, OBERHOFER, DAGMAR, PAVIČIĆ, ANA MARIJA, TOMIČIĆ, MAJA |
| المصدر: | Acta medica Croatica ; ISSN 1330-0164 (Print) ; ISSN 1848-8897 (Online) ; Volume 71 ; Issue 2 |
| بيانات النشر: | Academy of Medical Sciences of Croatia |
| سنة النشر: | 2017 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | vankomicin, trombocitopenija izazvana lijekovima, kritični bolesnici, vancomycin, drug-induced thrombocytopenia, critically ill patients |
| الوصف: | Vankomicin i drugi lijekovi mogu se previdjeti kao uzrok trombocitopenije kod kritičnih bolesnika kod kojih su sepsa, heparinom izazvana trombocitopenija i diseminirana intravaskularna koagulopatija češći uzroci. U radu je prikazan slučaj teške trombocitopenije kod 53-godišnje bolesnice podvrgnute hitnoj laparotomiji zbog difuznog peritonitisa koja se razvila 24 sata nakon uvođenja terapije vankomicinom. Broj trombocita prije terapije vankomicinom iznosio je 101 x 109/L, a nakon 2 doze broj je pao na 8 x 109/L bez kliničkih znakova krvarenja. Višestruke transfuzije trombocita podigle su broj trombocita najviše do 48 x 109/L. Vankomicin je isključen iz terapije kao mogući uzrok trombocitopenije, a uveden je ciprofl oksacin. U serumu bolesnice dokazana su IgG antitrombocitna antitijela i uveden je u terapiju metilprednizolon 40 mg/dan. Stanje bolesnice i broj trombocita postepeno su se popravljali te je preoperativna vrijednost trombocita postignuta 10 dana nakon ukidanja vankomicina. Nalaz antitrombocitnih antitijela ovisnih o vankomicinu potvrđuje dijagnozu vankomicinom izazvane trombocitopenije, ali je test dostupan samo u specijaliziranim laboratorijima. ; Vancomycin and other drugs are often overlooked as causes of thrombocytopenia in critically ill patients in whom sepsis, heparin-induced thrombocytopenia and disseminated intravascular coagulation are considered as more common causes. We report a case of profound vancomycin-induced thrombocytopenia developing within 24 hours of treatment initiation. A 53-year-old woman with no signifi cant comorbidities underwent laparoscopic surgery for a left-sided ovarian tumor. Two days later, she developed severe sepsis with symptoms and signs of acute abdomen. Emergency laparotomy revealed a lesion of the sigmoid colon and fi brinopurulent peritonitis. Empirical antibiotic therapy started intraoperatively included i.v. metronidazole and gentamicin. On postoperative day 2, it was changed to i.v. meropenem and vancomycin according to the results of microbiological ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | Croatian |
| العلاقة: | http://hrcak.srce.hr/186126Test |
| الإتاحة: | http://hrcak.srce.hr/186126Test http://hrcak.srce.hr/file/274506Test |
| حقوق: | info:eu-repo/semantics/openAccess ; The full text of the journal may be used for personal or educational purposes, respecting copyrights of authors and publishers. |
| رقم الانضمام: | edsbas.8F73B0FE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |