التفاصيل البيبلوغرافية
| العنوان: |
Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura. |
| المؤلفون: |
de la Rubia, Javier1, López, Aurelio1, Arriaga, Francisco1, Cid, Ana Rosa1, Vicente, Ana Isabel1, Marty, Maria Luisa1, Sanz, Miguel A.1 |
| المصدر: |
Acta Haematologica. 1999, Vol. 102 Issue 1, p12-16. 5p. |
| مصطلحات موضوعية: |
*PLASMA exchange (Therapeutics), *STEROIDS, *THERAPEUTICS, *THROMBOTIC thrombocytopenic purpura, *THROMBOPENIC purpura |
| مستخلص: |
We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE) and steroids. Nine patients (82%) achieved complete remission (CR) after a median of 6 rounds of PE (range 2–22). There were 3 early relapses managed in the same way as the initial episode. One patient relapsed 23 months after diagnosis achieving CR with standard therapy; another patient suffered several relapses, and splenectomy was performed after the last one. Three patients died, 2 of them with resistant disease 9 and 38 days after diagnosis, and the remaining one died due to AIDS-related complications while he was in CR. Eight patients are alive in CR with a median follow-up of 38 months (range 8–74). The combination of PE and steroids is a well-tolerated and effective treatment of TTP, but improvements in therapy are needed to manage refractory patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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