التفاصيل البيبلوغرافية
| العنوان: |
Dramatic Recovery after Etoposide Phosphate Infusion for Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome following Treatment with Tisagenlecleucel in a Young Patient with Relapsed Acute Lymphoblastic Leukemia: A Case Report. |
| المؤلفون: |
Peterlin, Pierre, Garnier, Alice, Le Bourgeois, Amandine, Jullien, Maxime, Seguin, Amélie, Eveillard, Marion, Béné, Marie-Christine, Guillaume, Thierry, Chevallier, Patrice |
| المصدر: |
Acta Haematologica; Sep2022, Vol. 145 Issue 5, p537-541, 5p |
| مصطلحات موضوعية: |
HEMOPHAGOCYTIC lymphohistiocytosis, LYMPHOBLASTIC leukemia, ACUTE leukemia, MACROPHAGE activation syndrome, ETOPOSIDE, PHOSPHATES |
| مستخلص: |
The occurrence of a secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) after CAR T-cell infusion is very rare and mostly fatal. Treatment recommendations for such a complication are not yet established. Here, we report the dramatic recovery of HLH/MAS following tisagenlecleucel infusion in a young patient with relapsed acute lymphoblastic leukemia using etoposide phosphate (EP). We propose that monitoring for the occurrence of HLH/MAS should be part of surveillance after CAR T-cell infusion and that EP treatment appears to be useful to control this severe and rare complication. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
