Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus
| العنوان: | Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus |
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| المؤلفون: | Tamara Sharshakova, Olga Vasilkova, Tatiana Mokhort, Noboru Takamura, Naomi Hayashida |
| المصدر: | Acta diabetologica. 48(4) |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Leptin, Male, medicine.medical_specialty, Bone density, Endocrinology, Diabetes and Metabolism, Bone remodeling, chemistry.chemical_compound, Endocrinology, Bone Density, Internal medicine, Diabetes mellitus, Internal Medicine, Medicine, Humans, Aged, Bone mineral, Glycated Hemoglobin, Triglyceride, business.industry, Type 2 Diabetes Mellitus, General Medicine, Middle Aged, medicine.disease, Lipoproteins, LDL, Type 2 diabetes mellitus (T2DM), chemistry, Diabetes Mellitus, Type 2, business, Lipoproteins, HDL, Body mass index, Bone mineral density (BMD) |
| الوصف: | To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45-65years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A(1c), immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r=0.23, P=0.002) and leptin (r=0.21, P=0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (β=0.058, P=0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is necessary to confirm this association and to develop ways to correct abnormalities of bone metabolism in patients with T2DM. Acta Diabetologica, 48(4), pp.291-295; 2011 |
| وصف الملف: | application/pdf |
| تدمد: | 1432-5233 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffb4f1c10b3f23b12de5b9f6dabfdfcTest https://pubmed.ncbi.nlm.nih.gov/21327983Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ffb4f1c10b3f23b12de5b9f6dabfdfc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 |
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