Elevated hepatocyte growth factor in sera from patients with insulin-dependent diabetes mellitus
| العنوان: | Elevated hepatocyte growth factor in sera from patients with insulin-dependent diabetes mellitus |
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| المؤلفون: | Terje Espevik, Anders Sundan, Magne Børset, B. Kulseng |
| المصدر: | Acta Diabetologica. 35:77-80 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Endocrinology, Reference Values, Diabetes mellitus, Internal medicine, Blood plasma, Internal Medicine, medicine, Albuminuria, Humans, Glycated Hemoglobin, Type 1 diabetes, Proteinuria, Hepatocyte Growth Factor, business.industry, Insulin, Osmolar Concentration, General Medicine, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Female, Microalbuminuria, medicine.symptom, business, Retinopathy |
| الوصف: | Hepatocyte growth factor (HGF) is a pleiotropic cytokine known to be involved in tissue regeneration and repair. We measured serum levels of HGF in patients with insulin-dependent diabetes mellitus (type 1). The patients were divided into four groups: (1) 10 patients at clinical presentation before insulin treatment; (2) 19 patients with newly diagnosed type 1 diabetes (diabetes duration 1/2-3 years); (3) 14 patients with long-standing type 1 diabetes without renal involvement (diabetes duration10 years, and urinary albumin excretion (UAER)20 microg/ min); and (4) 20 patients with long-standing type I diabetes with renal involvement (diabetes duration10 years and UAER 20-500 microg/min). Sera from 24 age- and sex-matched healthy blood donors constituted a control group. The HGF levels of the four groups were (mean +/- SD); group 1, 0.74+/-0.14; group 2, 0.78+/-0.40; group 3, 0.86+/-0.42; group 4, 0.79+/-0.27 ng/ml, compared to 0.43+/-0.24 ng/ml in the control group (P0.0008). HGF levels were not significantly different between the four patient groups. The elevated serum HGF levels did not correlate with complications related to type 1 diabetes, such as UAER, retinopathy and macrovascular complications, suggesting that HGF levels were not associated with the type 1 diabetes complications. In conclusion, our results show that type 1 diabetic patients have increased serum HGF levels compared with controls and that HGF is elevated to the same extent in newly diagnosed as well as in long-standing type 1 diabetes. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0599f6b7d65b81ddc7f2ec72a8df4f3fTest https://doi.org/10.1007/s005920050107Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0599f6b7d65b81ddc7f2ec72a8df4f3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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