The association of serum total sialic acid/total protein ratio with diabetic parameters in young type 1 diabetic patients
| العنوان: | The association of serum total sialic acid/total protein ratio with diabetic parameters in young type 1 diabetic patients |
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| المؤلفون: | Sabahattin Muhtaroglu, Selim Kurtoglu, Mehmet Keskin, Mehmet Emre Atabek |
| المصدر: | Acta Diabetologica. 43:1-5 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, viruses, Endocrinology, Diabetes and Metabolism, Population, Blood lipids, Excretion, chemistry.chemical_compound, Endocrinology, Glycolipid, Reference Values, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Child, education, neoplasms, Triglycerides, Total protein, education.field_of_study, business.industry, organic chemicals, Blood Proteins, General Medicine, biochemical phenomena, metabolism, and nutrition, medicine.disease, N-Acetylneuraminic Acid, Sialic acid, Cholesterol, Diabetes Mellitus, Type 1, Blood pressure, chemistry, Immunology, Regression Analysis, Female, sense organs, business, Biomarkers |
| الوصف: | Sialic acid is a terminal component of the non-reducing end of carbohydrate chains of glycoproteins and glycolipids. The purpose of this study was to estimate serum total sialic acid (TSA) concentrations and serum TSA/serum total protein (TP) ratios in young type 1 diabetic subjects and to investigate their association with diabetes-related parameters in that population. Twentyfour young type 1 diabetic patients and 20 healthy controls were enrolled in this study. Serum TSA and serum TSA/TP ratio were measured in both groups. Moreover, we looked for correlation among serum TSA, serum TSA/TP ratio and clinically relevant parameters such as urinary albumin excretion, blood pressure, diabetes duration, HbA1c, daily insulin dose, serum lipids and magnesium in type 1 diabetic patients. Serum TSA concentrations and serum TSA/TP ratio showed no statistical difference between patients and controls (p > 0.05). While serum TSA concentrations only correlated with urinary albumin excretion (r=0.44, p=0.028), serum TSA/TP ratio correlated with diastolic blood pressure (r=0.48, p=0.015), diabetes duration (r=0.46, p=0.022) and urinary albumin excretion (r=0.53, p=0.007) in the diabetic subjects. We concluded that serum TSA/TP ratio might be a better indicator than serum TSA as an index of diabetic complications. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259727b4fb064de7bd59823f6f40e60aTest https://doi.org/10.1007/s00592-006-0202-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....259727b4fb064de7bd59823f6f40e60a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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