دورية أكاديمية
Parkinsonova bolest ; Parkinson's disease
| العنوان: | Parkinsonova bolest ; Parkinson's disease |
|---|---|
| المؤلفون: | Béné, Raphael, Antić, Sonja, Budišić, Mislav, Lisak, Marijana, Trkanjec, Zlatko, Demarin, Vida, Podobnik-Šarkanji, Slava |
| المصدر: | Acta Clinica Croatica (acta@kbcsm.hr); Vol.48 No.3 |
| بيانات النشر: | Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; acta@kbcsm.hr |
| سنة النشر: | 2009 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | Parkinsonova bolest - etiologija, Parkinsonova bolest - dijagnostika, Parkinsonova bolest - terapija, Parkinson disease - etiology, Parkinson disease - diagnosis, Parkinson disease - therapy |
| الوصف: | Parkinsonova bolest je jedna od najčešćih neurodegenerativnih bolesti koju uzrokuje degeneracija dopaminergičnih neurona u supstanciji nigri. Neuropatološko obilježje Parkinsonove bolesti je nalaz Lewyjevih tjelešaca koja su najvećim dijelom građena od alfa sinukleina i ubikvitina. Pojavu Parkinsonove bolesti uzrokuje međudjelovanje genetskih čimbenika i čimbenika iz okoliša, ali točan mehanizam nastanka bolesti nije u potpunosti poznat. Najznačajniji motorni simptomi bolesti su bradikinezija, rigiditet, tremor u mirovanju i posturalna nestabilnost. Najznačajniji lijek u liječenju Parkinsonove bolesti je L-dopa, a primjenjuju se i dopaminergični agonisti, inhibitori monoaminooksidaze B (MAO-B), inhibitori katehol-O-metil transferaze (COMT), amantadin i anukolinergični lijekovi. ; Parkinson's disease is one of the most common neurodegenerative diseases caused by degeneration of dopaminergic neurons in substantia nigra. The neuropathologic hallmark of Parkinson's disease is the presence of Lewy bodies composed mostly of alpha-synuclein and ubiquitin. It is believed that the occurrence of Parkinson's disease is due to a combination of genetic and environmental factors, but the exact mechanism of Parkinson's disease development is not fully elucidated. The most characteristic motor symptoms for Parkinson's disease include bradykinesia, rigidity, resting tremor and postural instability, while many patients also have non-motor signs and symptoms. The key therapeutic agent in the treatment of Parkinson's disease is L-dopa, and the others are dopaminergic agents, monoamine oxidase-B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, amantadine and anticholinergic agents. |
| نوع الوثيقة: | text |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/45288Test; http://hrcak.srce.hr/file/70065Test |
| الإتاحة: | http://hrcak.srce.hr/45288Test http://hrcak.srce.hr/file/70065Test |
| رقم الانضمام: | edsbas.15D0DCEA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |