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1دورية أكاديمية
المؤلفون: Maja Baretić, Ivana Kraljević, Ivana Pavlić Renar
المصدر: Acta Clinica Croatica, Vol 55., Iss 1., Pp 93-98 (2016)
مصطلحات موضوعية: Diabetes mellitus, type 1 – complications, Hypoglycemia prevention and control, Insulin – pump administration and dosage, Insulin infusion systems, Insulin pump, Adult, Medicine
الوصف: The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.
وصف الملف: electronic resource
العلاقة: https://hrcak.srce.hr/file/237763Test; https://doaj.org/toc/0353-9466Test; https://doaj.org/toc/1333-9451Test
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المؤلفون: Vesna Kušec, Ivana Pavlić-Renar, Velimir Altabas, Valentina Uroić, Maja Baretić
المصدر: Acta Clinica Croatica
مصطلحات موضوعية: Adult, Male, 030213 general clinical medicine, 0209 industrial biotechnology, Taste, medicine.drug_class, medicine.medical_treatment, Glucagon-like peptide 1, Food preferences, Cross-over studies, Double-blind method, Physiology, 02 engineering and technology, Placebo, 03 medical and health sciences, Food Preferences, 020901 industrial engineering & automation, 0302 clinical medicine, Sex Factors, Double-Blind Method, Tongue, Glucagon-Like Peptide 1, medicine, Humans, Original Scientific Papers, Saline, Cross-Over Studies, business.industry, digestive, oral, and skin physiology, Taste Perception, General Medicine, Middle Aged, Crossover study, Glucagon-like peptide-1, medicine.anatomical_structure, Estrogen, Female, business, Hormone
الوصف: SUMMARY Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue. The aim of the study was to find out how gut hormone glucagon-like peptide-1 (GLP-1) influences taste preference. Fourteen healthy participants (six male and eight female) were included in this double-blind, placebo-controlled crossover study. After overnight fast and salty fluid (oral sodium load), participants were randomized to receive placebo (500 mL of 0.9% saline) or GLP-1 infusion (1.5 pmol/kg/min) over a 3-hour period. At the end of infusion, participants chose food preferences from illustrations of food types representing 5 tastes. After 7 days, the protocol was repeated, this time those that had received placebo first got GLP-1 infusion, and those having received GLP-1 first got placebo. Change of taste preference after GLP-1 infusion but not after placebo was reported as response, and non-response was reported in case of taste persistence. A statistically significant difference in response type was found between genders, with women being more likely to change their taste preference after GLP-1 than men. The change of taste upon GLP-1 infusion observed in women might be ascribed to estrogen weight-lowering effects accomplished by receptor-mediated delivery.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee04b2d4aa40cbd55b914e5fc9a8c820Test
https://pubmed.ncbi.nlm.nih.gov/31819319Test -
3
المؤلفون: Ivana Pavlić Renar, Maja Baretić, Ivana Kraljević
المصدر: Acta Clinica Croatica, Vol 55., Iss 1., Pp 93-98 (2016)
مصطلحات موضوعية: Blood Glucose, Male, Insulin pump, Adult, Pediatrics, medicine.medical_specialty, Croatia, medicine.medical_treatment, lcsh:Medicine, 030209 endocrinology & metabolism, Hypoglycemia prevention and control, Hypoglycemia, type 1 diabetes, insulin pump therapy, indication, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Insulin – pump administration and dosage, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, Young adult, Retrospective Studies, Glycemic, Glycated Hemoglobin, Diabetes mellitus, type 1 – complications, business.industry, lcsh:R, nutritional and metabolic diseases, General Medicine, medicine.disease, Insulin infusion systems, Surgery, Diabetes Mellitus, Type 1, Female, business, Polyneuropathy, Retinopathy
الوصف: The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a6212ada60fb8a251219c27f44cc3Test
http://hrcak.srce.hr/file/237763Test -
4
المصدر: Acta clinica Croatica
Volume 56
Issue 2.
Acta Clinica Croatica, Vol 56, Iss 2., Pp 255-261 (2017)مصطلحات موضوعية: Male, Herpesvirus 4, Human, medicine.medical_treatment, viruses, 030232 urology & nephrology, lcsh:Medicine, Cytomegalovirus, 030230 surgery, BIOMEDICINE AND HEALTHCARE. Public Health and Health Care. Epidemiology, medicine.disease_cause, Gastroenterology, Immunoglobulin G, Serology, 0302 clinical medicine, Seroepidemiologic Studies, Prevalence, Renal dialysis, Herpesviridae, biology, Herpesvirus 3, human, Herpesvirus 1, human, General Medicine, Herpesviridae Infections, Hemodijaliza, Middle Aged, Cytomegalovirus Infections, Female, Hemodialysis, Adult, medicine.medical_specialty, Croatia, Hrvatska, Congenital cytomegalovirus infection, Herpesvirus 3, humani, Enzyme-Linked Immunosorbent Assay, Herpesvirus 1, humani, Virus, 03 medical and health sciences, Immunocompromised Host, Renal Dialysis, Internal medicine, medicine, Seroprevalence, Humans, business.industry, lcsh:R, Herpes simplex virus, Varicella-zoster virus, Epstein-barr virus, BIOMEDICINA I ZDRAVSTVO. Javno zdravstvo i zdravstvena zaštita. Epidemiologija, medicine.disease, Virology, Citomegalovirus, herpesvirus 4, humani, biology.protein, business, Cytomegalovirus, herpesvirus 4, human
الوصف: Virusi iz herpes grupe (herpes simpleks virus, HSV; varičela-zoster virus, VZV; citomegalovirus, CMV; Epstein-Barrov virus, EBV) su značajan uzrok smrtnosti u imunokompromitiranih osoba. Cilj rada bio je analizirati učestalost HSV-1, HSV-2, VZV, CMV i EBV u bolesnika koji se liječe hemodijalizom. Tijekom trogodišnjeg razdoblja (2013.-2015.) ispitano je ukupno 152 uzastopno pristiglih uzoraka seruma bolesnika na hemodijalizi te 150 uzoraka seruma zdravih osoba (kontrolna skupina) na prisutnost herpes virusnih IgM/IgG protutijela. Serološko testiranje učinjeno je pomoću komercijalnog dijagnostičkog imunoenzimnog testa (ELISA) ili imunoenzimnog testa s fluorescentnom detekcijom (ELFA). Bolesnici na hemodijalizi bili su značajno češće CMV IgG seropozitivni u odnosu na kontrolnu skupinu (88,2% prema 78,7%, p=0,011). Nadalje, seroprevalencija HSV-1 i VZV također je bila viša u bolesnika na hemodijalizi, no statistička značajnost nije dostignuta (85,5% prema 80,0%, p=0,054; 99,3% prema 96,0%, p=0,051). Učestalost HSV-2 i EBV protutijela nije se razlikovala između skupina (12,5% prema 12,7%, p=0,137, odnosno 98,0% prema 95,3%, p=0,113). IgG seroprevalencija nije se razlikovala u odnosu na spol i mjesto prebivališta. Rezultati logističke regresije pokazali su da je starija životna dob značajan čimbenik rizika za CMV i EBV seropozitivnost (porastom dobi za jednu godinu CMV OR=1,055; 95%CI=1,030-1,080; EBV OR=1,075, 95%CI=1,023-1,130). Herpes group viruses (herpes simplex virus, HSV; varicella-zoster virus, VZV; cytomegalovirus, CMV; and Epstein-Barr virus, EBV) remain an important cause of morbidity in immunocompromised persons. The aim of the study was to analyze the prevalence of HSV-1, HSV-2, VZV, CMV and EBV in patients undergoing hemodialysis. During a three-year period (2013-2015), 152 consecutive serum samples from hemodialysis patients and 150 healthy subjects (control group) were tested for the presence of IgM/IgG antibodies to herpes group viruses. Serologic tests were performed using a commercial enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunofluorescent assay (ELFA). Hemodialysis patients showed significantly higher CMV IgG seropositivity compared to controls (88.2% vs. 78.7%, p=0.011). In addition, seroprevalence rates of HSV-1 and VZV were higher in hemodialysis patients; however, these differences did not reach statistical significance (85.5% vs. 80.0%, p=0.054 and 99.3% vs. 96.0%, p=0.051, respectively). The prevalence of HSV-2 and EBV was similar in both groups (12.5% vs. 12.7%, p=0.137 and 98.0% vs. 95.3%, p=0.113, respectively). There was no difference in IgG seropositivity according to gender and place of residence. Logistic regression showed that older age was a significant predictor for CMV and EBV IgG seropositivity (increase in age by one year: CMV OR=1.055; 95%CI=1.030-1.080 and EBV OR=1.075, 95%CI=1.023-1.130).
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646ca838ef18763c2418d9213a1674cfTest
https://pubmed.ncbi.nlm.nih.gov/29485792Test -
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المصدر: Acta Clinica Croatica, Vol 54., Iss 4., Pp 409-415 (2015)
مصطلحات موضوعية: Adult, musculoskeletal diseases, animal structures, Genotype, lcsh:Medicine, Vascular stiffness, Carotid Intima-Media Thickness, Plasminogen Activator Inhibitor 1, Humans, Prospective Studies, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Polymorphism, Genetic, fungi, lcsh:R, Brain, Middle Aged, Atherosclerosis, Magnetic Resonance Imaging, body regions, Stroke, nervous system, Carotid artery diseases, Migraine disorders, Female, migraine, carotid stiffness, genetic polymorphism
الوصف: Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42 ± 10.61 years) were compared with 45 controls (30 women) with no prior history of repeating headache (mean age 38.94 ± 5.46 years) using E-tracking software on Alpha 10 ultrasound platform. Student's t-test was used on statistical analysis with alpha0.05. All tested carotid vascular parameters were worse in patients with migraine including increased intima-media thickness, greater carotid diameter and carotid diameter change, as well as several arterial stiffness indices. Additionally, patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected. Computed tomography and magnetic resonance imaging of the brain showed WML in 11 patients, four of them migraine with aura patients. Since we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs, we propose prospective ultrasound monitoring in such patients, especially those with detected WML, in order to timely commence more active and specific preventive stroke management strategies.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4d979376a08406912054c0c000a7dfd8Test
http://hrcak.srce.hr/file/228218Test -
6
المؤلفون: Maja Baretić, Ivana Kraljević, Ivana Pavlić Renar
المصدر: Acta clinica Croatica
Volume 55.
Issue 1.مصطلحات موضوعية: Dijabetes melitus, tip 1 – komplikacije, Hipoglikemija – prevencija i kontrola, Inzulin – primjena i doziranje, Inzulin, sustavi za infuziju, Inzulinska crpka, Odrasla osoba, nutritional and metabolic diseases, Diabetes mellitus, type 1 – complications, Hypoglycemia prevention and control, Insulin – pump administration and dosage, Insulin infusion systems, Insulin pump, Adult
الوصف: The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.
Cilj studije bio je istražiti koji su odrasli bolesnici s tipom 1 dijabetesa liječeni s više dnevnih doza inzulina najbolji kandidati za liječenje inzulinskom crpkom, uzimajući u obzir njihovu ograničenu dostupnost u Republici Hrvatskoj. Na Zavodu za endokrinologiju Interne klinike Kliničkoga bolničkog centra Zagreb praćeno je 145 bolesnika s tipom 1 dijabetesa (kod 52% njih je bolest dijagnosticirana u odrasloj dobi) u razdoblju od 2009. do 2014. godine. Kod 21 bolesnika (7 muškaraca i 14 žena, medijan dobi 27 godina) liječenje crpkom započelo je u odrasloj dobi. Petoro bolesnika je imalo kronične komplikacije (dvoje retinopatiju, jedan polineuropatiju, a dvoje je imalo i retinopatiju i neuropatiju). Medijan HbA1c prije započinjanja liječenja inzulinskom crpkom je bio 6,95%, a nakon godine dana terapije crpkom 6,5%. Bolesnici su bili razvrstani prema indikaciji za liječenje crpkom (učestale i/ili teške hipoglikemije, specifičan stil života, nepostizanje željenih ciljeva glikemije unatoč suradljivosti/nestabilan dijabetes te pretkoncepcija). Bolesnici su mogli ispunjavati i više od jedne indikacije. Na početku liječenja učestalost hipoglikemija se analizirala kontinuiranim praćenjem glukoze tijekom 5-6 dana, a reevaluacija je učinjena iz anamnestičkih podataka nakon 1 godine ± 3 mjeseca. Na samom početku liječenja bolesnici su imali 5 hipoglikemija/6 dana (30% noćnih), a nakon godine dana 1 hipoglikemiju/6 dana (bez noćnih). Wilcoxonov signed-rank test pokazao je statistički značajnu razliku u broju i učestalosti noćnih hipoglikemija te u HbA1c. Kod onih bolesnika u kojih je liječenje započelo inzulinskom crpkom s indikacijom hipoglikemije prije crpke medijan HbA1c je bio 6,7% sa 7 hipoglikemija/6 dana (50% noćnih). Nakon godinu dana medijan HbA1c je bio 6% s 1 hipoglikemijom /6 dana (bez noćnih). Kao zaključak, vodeća indikacija za liječenje inzulinskom crpkom u odraslih bolesnika je učestalost hipoglikemija, osobito noćnih.وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______951::55a3e3207cad8a2006306d60cb7d884eTest
https://hrcak.srce.hr/file/237763Test -
7
المؤلفون: Davorin Đanić, Alen Sekelj
المصدر: Acta Clinica Croatica, Vol 56, Iss 3, Pp 425-436 (2017)
مصطلحات موضوعية: Adult, Male, Pediatrics, medicine.medical_specialty, Lyme neuroborreliosis, Facial Paralysis, Serologic tests, Population, lcsh:Medicine, Lyme disease, Facial paralysis, Reflex, acoustic, Bell palsy, Herpesvirus 1, human, Audiometry, Acoustic impedance tests, Croatia, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Predictive Value of Tests, medicine, Paralysis, Humans, education, Fisher's exact test, education.field_of_study, Palsy, business.industry, lcsh:R, Bell Palsy, General Medicine, Middle Aged, Prognosis, medicine.disease, Facial nerve, 030205 complementary & alternative medicine, Lyme Neuroborreliosis, symbols, Female, medicine.symptom, business, 030217 neurology & neurosurgery
الوصف: Introduction and aim Lyme borreliosis is the most common tick-transmitted disease. It is characterized by three stages, which makes neuroborreliosis second so-called early disseminated stage. In numerous cases peripheral facial palsy is the only symptom and sign of neuroborreliosis. In endemic areas of borreliosis, every acute peripheral facial palsy indicates serological processing and implies a special approach to disease. There is a several predictors of peripheral facial palsy. They are showing us a possible etiology, therapy and prognosis of peripheral facial palsy. Whereas, there is a suspision that the treatment of peripheral facial palsy is more difficult and takes longer, including numerous sequaelae, purpose of research is finding and confirming the value of acoustic reflex and House Brackmann rating skale as prognostic indicators that will make therapy direction and rehab easier and more precise. In the final part of the study, testing to seropositivity will be done on population of Brodsko- Posavska county. Patients and methods Research included 176 patients with acute peripheral facial palsy who were after serological processing divided in three basic groups - borreliosis, Bell's palsy and peripheral facial palsy caused by HSV1 virus. Preliminary audiometry with timpanometry and acoustic reflexes was done on each patient, and a current condition of peripheral facial palsy was rated according to House Brackmann rating scale and photographed. The same testing was implemented in three other measurements - in 3., 6. and 12. week since hospitalization. Repeated serology was not implemented. Protocol criteria was in accordance with exclusion from the study. Every patient had given their consent to be included in research. Survival analysis will be used for data processing, one-way and two-way, analysis of variance, Chi- Square test, Fisher exact test, Kruskal Wallis test, Pearson Point-biserial correlation coefficient and Spearman's rank correlation coefficient. 93 Results In this research acoustic reflex and House Brackmann rating skale are being observed as predictors of peripheral facial palsy in neuroborreliosis. 35 out 176 patients with peripheral facial palsy had borreliosis, which makes incidence of peripheral facial palsy in borreliosis 19,88 %. The research of predictor function of acoustic reflex shows results of comparison of leason location for 4 measurement spots according to diagnosis. In each timepoint patients with diagnosis of Lyme disease had statistically significantly the biggest percentage of suprastapedial lesions, especially in the third week since hospitalization (mostly occurance of paralysis as well) (p < 0,001), as well as in measuring that occured later, all the way to the end of study in the 12. week since paralysis occurance (p = 0,001). Comparing to the time needed to recover, result of analysis shows how group of patients with Lyme disease took the longest to recover (p < 0,001). Among the patients with borreliosis, a bit more than half of them had recovered until the sixth week, while the most patients with Bell's paralysis had already recovered until the third week, and most of the patients with HSV1 did not even have suprastapedijalnu lesion in the first measurement whatsoever. 47% of patients with borreliosis recovered only in the 12. week comparing to Bell's paralysis and patients with HSV1. Testing predictor function of House Brakmann rating scale, patients from all three groups had similar average results on HB scale in the first and the last measurement. However, result on the scale was falling much slower for patients with borreliosis. Comparing the speed of recovery it was shown that there are significant differences in time before until the patient had recovered, or in other words the patient had result 1 on HB scale depending on diagnosis (p < 0,001). Patients with Lyme disease diagnosis took longer to recover than patients with Bell's paralysis and HSV1: more than half of patients with borreliosis had not recovered until the 12. week or did not recover at all during the research while most of the patients with Bell's paralysis and HSV1 had already recovered in the 3. week since occurance of palsy. In additional analysis there was confirmed that all of the patients (100 %) with HSV1 who had suprastapedial lesion in the first measurement were exposed to hypothermia, which confirms the suspision related to etiology, vasospasm or reactivation of the virus. In comparison to acoustic reflex and House Brackmann rating scale, the biggest difference in the classification of the patients was that House Brackmann scale comparing to acoustic reflex shows gradual subsequent recovery. Testing feeling as prodromal sign of peripheral facial palsy in neuroborrealiosis, bigger number of the patients with Lyme disease had headache comparing to other two diagnosis. There were not found any statistically significant differences in recovery cochleostapedial reflex and recovery of facial nerve according to House Breckamm skale that was related to the therapy. At the end, conducting evaluation of seropositivity of the population of Brodsko- posavska county, it was confirmed seroprevalence with borreliosis of 22%, which makes this region a possible endemic area. Conclusion Conducting this research it was proven that cochlostapedial reflex and House Brackmann scale are valuable prognostic indicators of peripheral facial palsy in patients with neuroborreliosis.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba69bbd8bf3db40201f535a118b762fTest
https://doi.org/10.20471/acc.2017.56.03.09Test -
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المؤلفون: Ayla, Aktulay, Yaprak, Engin-Ustun, Mehmet Sahin, Ozkan, Salim, Erkaya, Mustafa, Kara, Oktay, Kaymak, Nuri, Danisman
المصدر: Acta clinica Croatica. 54(4)
مصطلحات موضوعية: Adult, Blood Glucose, Neutrophils, Glucose Tolerance Test, Body Mass Index, Diabetes, Gestational, Young Adult, Adipokines, Pregnancy, Case-Control Studies, Lectins, Humans, Female, Chitinase-3-Like Protein 1, Lymphocytes, Glycoproteins
الوصف: The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like pro- tein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (± 2 years) and pre-pregnancy body mass index (± 2 kg/m²). The YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statisti- cally significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/ mL vs. 159.2 (14-290) ng/mL, p = 0.007). NLR and PLR were significantly higher in GDM com- pared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::19d7c0ac99e4658ede26f8e080955eceTest
https://pubmed.ncbi.nlm.nih.gov/27017722Test -
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المؤلفون: Kajo, Bućan, Lovro, Bojić, Damir, Fabijanić, Davor, Galetović, Vesna, Čapkun, Dobrila Karlica, Utrobičić, Ivona, Bućan
المصدر: Acta clinica Croatica. 53(4)
مصطلحات موضوعية: Adult, Male, Ventricular Dysfunction, Left, Young Adult, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Risk Factors, Albuminuria, Humans, Female, Comorbidity, Middle Aged, Severity of Illness Index
الوصف: Vascular endothelial dysfunction is a basic etiologic factor for the development of late clinical complications in patients with diabetes mellitus type 1, such as diabetic retinopathy, diabetic nephropathy (which is characterized at the very beginning by microalbuminuria), and left ventricular cardiac dysfunction. The aims of this study were to determine the prevalence of asymptomatic left ventricular systolic dysfunction in patients with diabetes mellitus type 1 and with or without diabetic retinopathy and microalbuminuria, and to correlate the duration of diabetes with the dynamics of diabetic retinopathy, microalbuminuria and asymptomatic left ventricular dysfunction development in these patients. One-hundred and twenty selected patients with diabetes mellitus type 1 were examined by ophthalmologist and cardiologist. All patients underwent ergometric testing and two-dimensional (2-D) echocardiography with pulsed Doppler. Patients were divided into three groups according to their fundus findings and microalbuminuria: (1) patients without diabetic retinopathy and without microalbuminuria (n = 40); (2) patients with diabetic retinopathy without microalbuminuria (n = 40); and (3) patients with diabetic retinopathy and microalbuminuria (n = 40). All three groups of patients with diabetes mellitus type 1 (with low cardiovascular risk, regulated blood sugar, and without diabetic neuropathy) had echocardiographic values in the normal range. We found no statistically significant correlation between the duration of diabetes mellitus type 1 and echocardiographic values.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::062860f4877e9e0fab83c002c3862bd9Test
https://pubmed.ncbi.nlm.nih.gov/29046021Test -
10
المؤلفون: Tomislav, Bulum, Lea, Duvnjak
المصدر: Acta clinica Croatica. 52(1)
مصطلحات موضوعية: Adult, Blood Glucose, Male, Adolescent, Croatia, Risk Assessment, Sensitivity and Specificity, Body Mass Index, Leukocyte Count, Predictive Value of Tests, Risk Factors, Prevalence, Humans, Homocysteine, Triglycerides, Aged, Glycated Hemoglobin, Metabolic Syndrome, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, C-Reactive Protein, Diabetes Mellitus, Type 1, Ferritins, Disease Progression, Female, Insulin Resistance, Waist Circumference, Biomarkers
الوصف: Although insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes. Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk of cardiovascular disease in this population. To investigate the relationship of insulin resistance with metabolic and inflammatory parameters we divided 304 patients according to median estimated glucose disposal rate (eGDR = 9.72 mgkg(-1)min(-1)) into lower (n = 153) and higher (n = 151) insulin sensitivity groups. Patients with lower insulin sensitivity had higher levels of serum lipids (except for HDL cholesterol), duration of diabetes, daily insulin dose, white blood cell count, C-reactive protein, homocysteine and ferritin. Spearman correlation analysis showed significant associations between individual components of insulin resistance and various metabolic and inflammatory parameters. Multiple logistic regression models found significant association of age, sex, duration of diabetes, serum lipids, daily insulin dose, white blood cell count and ferritin with progression to insulin resistance. The presence of insulin resistance indicates a greater risk of micro- and macrovascular disease and health care professionals need to be alerted that this subset of individuals with type 1 diabetes will require stringent control of hypertension, glycemia and serum lipids.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::c786c5d9d504c7cf24802dd29fa697abTest
https://pubmed.ncbi.nlm.nih.gov/23837272Test
