Seroprevalencija na viruse iz herpes grupe u bolesnika na hemodijalizi
| العنوان: | Seroprevalencija na viruse iz herpes grupe u bolesnika na hemodijalizi |
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| المؤلفون: | Maja Bogdanić, Tatjana Vilibić-Čavlek, Nataša Beader, Branko Kolarić, Irena Tabain |
| المصدر: | Acta clinica Croatica Volume 56 Issue 2. Acta Clinica Croatica, Vol 56, Iss 2., Pp 255-261 (2017) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Herpesvirus 4, Human, medicine.medical_treatment, viruses, 030232 urology & nephrology, lcsh:Medicine, Cytomegalovirus, 030230 surgery, BIOMEDICINE AND HEALTHCARE. Public Health and Health Care. Epidemiology, medicine.disease_cause, Gastroenterology, Immunoglobulin G, Serology, 0302 clinical medicine, Seroepidemiologic Studies, Prevalence, Renal dialysis, Herpesviridae, biology, Herpesvirus 3, human, Herpesvirus 1, human, General Medicine, Herpesviridae Infections, Hemodijaliza, Middle Aged, Cytomegalovirus Infections, Female, Hemodialysis, Adult, medicine.medical_specialty, Croatia, Hrvatska, Congenital cytomegalovirus infection, Herpesvirus 3, humani, Enzyme-Linked Immunosorbent Assay, Herpesvirus 1, humani, Virus, 03 medical and health sciences, Immunocompromised Host, Renal Dialysis, Internal medicine, medicine, Seroprevalence, Humans, business.industry, lcsh:R, Herpes simplex virus, Varicella-zoster virus, Epstein-barr virus, BIOMEDICINA I ZDRAVSTVO. Javno zdravstvo i zdravstvena zaštita. Epidemiologija, medicine.disease, Virology, Citomegalovirus, herpesvirus 4, humani, biology.protein, business, Cytomegalovirus, herpesvirus 4, human |
| الوصف: | Virusi iz herpes grupe (herpes simpleks virus, HSV; varičela-zoster virus, VZV; citomegalovirus, CMV; Epstein-Barrov virus, EBV) su značajan uzrok smrtnosti u imunokompromitiranih osoba. Cilj rada bio je analizirati učestalost HSV-1, HSV-2, VZV, CMV i EBV u bolesnika koji se liječe hemodijalizom. Tijekom trogodišnjeg razdoblja (2013.-2015.) ispitano je ukupno 152 uzastopno pristiglih uzoraka seruma bolesnika na hemodijalizi te 150 uzoraka seruma zdravih osoba (kontrolna skupina) na prisutnost herpes virusnih IgM/IgG protutijela. Serološko testiranje učinjeno je pomoću komercijalnog dijagnostičkog imunoenzimnog testa (ELISA) ili imunoenzimnog testa s fluorescentnom detekcijom (ELFA). Bolesnici na hemodijalizi bili su značajno češće CMV IgG seropozitivni u odnosu na kontrolnu skupinu (88,2% prema 78,7%, p=0,011). Nadalje, seroprevalencija HSV-1 i VZV također je bila viša u bolesnika na hemodijalizi, no statistička značajnost nije dostignuta (85,5% prema 80,0%, p=0,054; 99,3% prema 96,0%, p=0,051). Učestalost HSV-2 i EBV protutijela nije se razlikovala između skupina (12,5% prema 12,7%, p=0,137, odnosno 98,0% prema 95,3%, p=0,113). IgG seroprevalencija nije se razlikovala u odnosu na spol i mjesto prebivališta. Rezultati logističke regresije pokazali su da je starija životna dob značajan čimbenik rizika za CMV i EBV seropozitivnost (porastom dobi za jednu godinu CMV OR=1,055; 95%CI=1,030-1,080; EBV OR=1,075, 95%CI=1,023-1,130). Herpes group viruses (herpes simplex virus, HSV; varicella-zoster virus, VZV; cytomegalovirus, CMV; and Epstein-Barr virus, EBV) remain an important cause of morbidity in immunocompromised persons. The aim of the study was to analyze the prevalence of HSV-1, HSV-2, VZV, CMV and EBV in patients undergoing hemodialysis. During a three-year period (2013-2015), 152 consecutive serum samples from hemodialysis patients and 150 healthy subjects (control group) were tested for the presence of IgM/IgG antibodies to herpes group viruses. Serologic tests were performed using a commercial enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunofluorescent assay (ELFA). Hemodialysis patients showed significantly higher CMV IgG seropositivity compared to controls (88.2% vs. 78.7%, p=0.011). In addition, seroprevalence rates of HSV-1 and VZV were higher in hemodialysis patients; however, these differences did not reach statistical significance (85.5% vs. 80.0%, p=0.054 and 99.3% vs. 96.0%, p=0.051, respectively). The prevalence of HSV-2 and EBV was similar in both groups (12.5% vs. 12.7%, p=0.137 and 98.0% vs. 95.3%, p=0.113, respectively). There was no difference in IgG seropositivity according to gender and place of residence. Logistic regression showed that older age was a significant predictor for CMV and EBV IgG seropositivity (increase in age by one year: CMV OR=1.055; 95%CI=1.030-1.080 and EBV OR=1.075, 95%CI=1.023-1.130). |
| وصف الملف: | application/pdf |
| تدمد: | 0353-9466 1333-9451 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646ca838ef18763c2418d9213a1674cfTest https://pubmed.ncbi.nlm.nih.gov/29485792Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....646ca838ef18763c2418d9213a1674cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03539466 13339451 |
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