التفاصيل البيبلوغرافية
| العنوان: |
Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats |
| المؤلفون: |
Yayi,Huang, Yeda,Xiao, Huaxin,Wang, Yang,Wu, Qian,Sun, Zhongyuan,Xia |
| المصدر: |
Acta Cirurgica Brasileira v.31 n.7 2016 |
| بيانات النشر: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| سنة النشر: |
2016 |
| المجموعة: |
SciELO Brazil (Scientific Electronic Library Online) |
| مصطلحات موضوعية: |
Toll-Like Receptor 7, Diabetes Mellitus, Ischemia, Reperfusion, Kidney, Rats |
| الوصف: |
PURPOSE: To determine whether Toll-like receptor 7 (TLR7) is the potential targets of prevention or progression in the renal ischemia/reperfusion (I/R) injury of STZ-induced diabetic rats. METHODS: Thirty six Sprague-Dawley rats were randomly arranged to the nondiabetic (ND) or diabetic group (DM), with each group further divided into sham (no I/R injury), I/R (ischemia-reperfusion) and CD (given by Chloroquine) group. Preoperatively, Chloroquine (40 mg/kg, intraperitoneal injection.) was administrated 6 days for treatment group. I/R animals were subjected to 25 min of bilateral renal ischemia. Renal function, histology, apoptosis, cytokines, expression of TLR7, MyD88 and NF-κB were detected. RESULTS: The serum levels of blood urea nitrogen, creatinine, IL-6 and TNF-α, apoptotic tubular epithelial cells, expression of TLR7, MyD88 and NF-κB were significantly increased in DM+I/R group, compared with ND+I/R group (p<0.05). All these changes were further improved by TLR7 inhibition Chloroquine except Paller scores (p<0.05). CONCLUSION: Toll-like receptor 7 inhibition attenuates the acute renal ischemia/reperfusion injury of STZ-induced diabetic in SD rats. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
text/html |
| اللغة: |
English |
| الإتاحة: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000700448Test |
| رقم الانضمام: |
edsbas.8F61C2EF |
| قاعدة البيانات: |
BASE |
