التفاصيل البيبلوغرافية
| العنوان: |
Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas |
| المؤلفون: |
Mancini, Stefano, Alboni, Silvia, Mattei, Giorgio, Rioli, Giulia, Sena, Paola, Marchi, Mattia, Sacchetti, Andrea, Boarino, Valentina, Roncucci, Luca, Galeazzi, Gian Maria, Ferrari, Silvia |
| المصدر: |
Acta Biomed |
| بيانات النشر: |
Mattioli 1885 |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Original Article, psy, socio |
| الوصف: |
BACKGROUND AND AIM OF THE WORK: Colorectal mucosal precancerous lesions, metabolic syndrome (MetS) and psychiatric disorders may share a common low-grade local and systemic inflammation. Aim is to report on preliminary data concerning a research adopting a psycho-neuro-endocrine-immune (PNEI) approach to study outpatients undergoing colonoscopy. METHODS: A sample of patients undergoing colonoscopy was cross-sectionally investigated. Data on colorectal adenomas, MetS, early atherosclerosis, anxious-depressive symptoms, personality traits, and inflammatory markers were statistically analyzed. RESULTS: Sixty-two patients were recruited (female 50%, mean age: 60.8±9.4 years). The prevalence of adenomas and MetS was respectively of 45.2% and 41.9%. Anxiety and depressive symptoms were detected in 16 (32.7%) and 9 (18.4%) subjects, respectively. The presence of adenomas positively correlated with male sex (p=0.01), age (p<0.01), IL-6 (p=0.03), hsCRP (p=0.04), and MetS (p=0.03); it was also associated with hsCRP concentration (aOR=3.81, p=0.03). CONCLUSIONS: Proinflammatory atherogenic status, psychological traits, increased mucosal inflammation, and metabolic parameters may share a common a pathogenic mechanism, worth studying. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975933Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975933Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.65EEBAD4 |
| قاعدة البيانات: |
BASE |
