التفاصيل البيبلوغرافية
| العنوان: |
Intravenous lidocaine increases the depth of anaesthesia of propofol for skin incision - a randomised controlled trial. |
| المؤلفون: |
WEBER, U.1, KRAMMEL, M.1, LINKE, S.1, HAMP, T.1, STIMPFL, T.2, REITER, B.2, PLÖCHL, W.1 |
| المصدر: |
Acta Anaesthesiologica Scandinavica. Mar2015, Vol. 59 Issue 3, p310-318. 9p. 1 Diagram, 2 Charts, 3 Graphs. |
| مصطلحات موضوعية: |
*GENERAL anesthesia, *PROPOFOL, *ANESTHESIA, *INTRAVENOUS anesthetics, *PHENOLS, *CLINICAL trials |
| مستخلص: |
Background The anaesthetic potency of intravenous propofol is quantified by its Cp50 value, which is defined as the plasma concentration required to prevent movement response in 50% of patients to surgical stimuli. We hypothesised that, in addition to propofol anaesthesia, an intravenous bolus of lidocaine 1.5 mg/kg will decrease the Cp50 value of propofol during anaesthesia. Methods We enrolled 54 elective surgical patients undergoing propofol-based anaesthesia, and randomised them to either lidocaine 1.5 mg/kg, lidocaine 0.5 mg/kg or placebo ( NaCl 0.9%) 3 min before skin incision. The propofol Cp50 value was then calculated using the 'up-and-down' method of Dixon and Massey. Results There was no significant reduction in propofol requirements after the administration of 0.5 mg/kg lidocaine from 8.5 μg/ml [confidence interval ( CI) 6.0-11.625] to 8.25 μg/ml ( CI 6.75-9.76); however, a bolus of 1.5 mg/kg lidocaine decreased the Cp50 value of propofol by 42% from 8.5 μg/ml ( CI 6.0-11.625) to 4.92 μg/ml ( CI 4.5-5.78) ( P < 0.05). Conclusion An intravenous bolus injection of 1.5 mg/kg lidocaine 2% caused a significant reduction of the propofol Cp50 value. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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