Comparison of a combination of midazolam and diazepam and midazolam alone as oral premedication on preanesthetic and emergence condition in children
| العنوان: | Comparison of a combination of midazolam and diazepam and midazolam alone as oral premedication on preanesthetic and emergence condition in children |
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| المؤلفون: | K. Fukunaga, S. Hirota, Y-C. P. Arai |
| المصدر: | Acta Anaesthesiologica Scandinavica. 49:698-701 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Apnea, Midazolam, Sedation, Sevoflurane, Adenoidectomy, Intubation, Intratracheal, Humans, Hypnotics and Sedatives, Medicine, Anesthesia, heterocyclic compounds, Mask induction, Child, Tonsillectomy, Behavior, Diazepam, business.industry, Infant, General Medicine, Surgery, Drug Combinations, Anesthesiology and Pain Medicine, Child, Preschool, Anesthesia Recovery Period, Female, Premedication, medicine.symptom, Anesthesia, Inhalation, business, Pediatric anesthesia, Preanesthetic Medication, medicine.drug |
| الوصف: | Background: Preanesthetic anxiety and emergence agitation are major challenges for anesthesiologists in pediatric anesthesia. Thus, midazolam has been used as premedication for children. However, midazolam alone is not effective for emergence agitation. The present study tested the effect of a combination of midazolam and diazepam on the preanesthetic condition and emergence behavior in children. Methods: Forty-two children were allocated to one of three groups: the NoPre group received no premedication; the Mi group received midazolam 0.5 mg kg−1 orally; and the Mi + Di group received midazolam 0.25 mg kg−1 and diazepam 0.25 mg kg−1 orally. When anesthesia was induced with 7% sevoflurane in 100% oxygen, qualities of mask induction and sedation were rated. Anesthesia was maintained with sevoflurane (3–5%) in 100% oxygen. During emergence from anesthesia, the score of the child's emergence behavior was rated. Results: Children in the Mi and Mi + Di groups were more sedated than those in the NoPre group. A combination of midazolam and diazepam provided a better quality of mask induction, when compared with no premedication. Also, the children in the Mi + Di group were less agitated than those in the other groups during the emergence. Conclusion: Children in the Mi + Di group were significantly more sedated at induction of anesthesia and less agitated during emergence from anesthesia. |
| تدمد: | 1399-6576 0001-5172 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b6cc6e7711dfc460f52a6a32fd10a1Test https://doi.org/10.1111/j.1399-6576.2005.00700.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c8b6cc6e7711dfc460f52a6a32fd10a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13996576 00015172 |
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