Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress
| العنوان: | Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress |
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| المؤلفون: | Stefania Pagliari, Eugenio Magnani, Francesca Pagliari, Enrico Traversa, Paolo Di Nardo, Corrado Mandoli, Silvia Licoccia, Giancarlo Forte, Giorgia Nardone, Marilena Minieri |
| المصدر: | ACS Nano. 6:3767-3775 |
| بيانات النشر: | American Chemical Society (ACS), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Materials science, Settore ING-IND/22 - Scienza e Tecnologia dei Materiali, Cellular differentiation, Cell, General Physics and Astronomy, medicine.disease_cause, Regenerative medicine, Mice, Microscopy, Electron, Transmission, nanoparticles . reactive oxygen species, cerium oxide , nanoparticles . reactive oxygen species, medicine, Animals, General Materials Science, Cytotoxicity, cerium oxide, Cell damage, chemistry.chemical_classification, Reactive oxygen species, Cell growth, Myocardium, Stem Cells, Settore CHIM/07 - Fondamenti Chimici delle Tecnologie, General Engineering, Cell Differentiation, Cerium, medicine.disease, Cell biology, Mice, Inbred C57BL, Oxidative Stress, medicine.anatomical_structure, chemistry, Immunology, Nanoparticles, Female, Oxidative stress |
| الوصف: | Cardiac progenitor cells (CPCs) are a promising autologous source of cells for cardiac regenerative medicine. However, CPC culture in vitro requires the presence of microenvironmental conditions (a complex array of bioactive substance concentration, mechanostructural factors, and physicochemical factors) closely mimicking the natural cell surrounding in vivo, including the capability to uphold reactive oxygen species (ROS) within physiological levels in vitro. Cerium oxide nanoparticles (nanoceria) are redox-active and could represent a potent tool to control the oxidative stress in isolated CPCs. Here, we report that 24 h exposure to 5, 10, and 50 μg/mL of nanoceria did not affect cell growth and function in cardiac progenitor cells, while being able to protect CPCs from H(2)O(2)-induced cytotoxicity for at least 7 days, indicating that nanoceria in an effective antioxidant. Therefore, these findings confirm the great potential of nanoceria for controlling ROS-induced cell damage. |
| تدمد: | 1936-086X 1936-0851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e468907e0a06b090c10fd39b39f4123Test https://doi.org/10.1021/nn2048069Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9e468907e0a06b090c10fd39b39f4123 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936086X 19360851 |
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