Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles
| العنوان: | Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles |
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| المؤلفون: | Zhencheng Sun, Wenshu Zheng, Jie Lian, Guoshuai Zhu, Wenwen Chen, Ping Hui, Songliang He, Xingyu Jiang, Jidong Wang |
| المصدر: | ACS Applied Materials & Interfaces. 11:45381-45389 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Staphylococcus aureus, Materials science, medicine.drug_class, Antibiotics, Metal Nanoparticles, Microbial Sensitivity Tests, 02 engineering and technology, Diamines, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Mice, Minimum inhibitory concentration, Drug Resistance, Bacterial, Escherichia coli, medicine, Animals, Humans, General Materials Science, Bovine serum albumin, biology, Pseudomonas aeruginosa, Serum Albumin, Bovine, Bacterial Infections, 021001 nanoscience & nanotechnology, Antimicrobial, Anti-Bacterial Agents, 0104 chemical sciences, Multiple drug resistance, Thiazoles, Colloidal gold, Biofilms, biology.protein, 0210 nano-technology, Nuclear chemistry |
| الوصف: | Nonantibiotic small molecule-modified gold nanoparticles (Au NPs) show great potential as an alternative for commercial antibiotics, yet their narrow antibacterial spectrum hinders the wide application in clinics. We observe that Au NPs cofunctionalized with both bovine serum albumin (BSA) and 4,6-diamino-2-pyrimidinethiol (DAPT) can generate conjugates (Au_DAPT_BSA) with progressive antimicrobial activities, including decreased minimal inhibitory concentration against Gram-negative bacteria and extended antibacterial spectrum against Gram-positive bacteria compared with DAPT-capped Au NPs (Au_DAPT). Au_DAPT_BSA induces no drug resistance and can significantly decrease the number of bacteria in the biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus. In addition, Au_DAPT_BSA exhibit in vivo healing efficiency for mice with subcutaneous abscesses caused by clinically isolated, multidrug resistant Escherichia coli or S. aureus without inducing detectable toxicity to the mammalian cells/animals. Our findings provide a new strategy for strengthening nanomaterial-based bactericides such as Au NPs, especially against drug-resistant bacterial infections. |
| تدمد: | 1944-8252 1944-8244 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b779c779ec2eae9dfad46f780b7a0023Test https://doi.org/10.1021/acsami.9b15107Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b779c779ec2eae9dfad46f780b7a0023 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19448252 19448244 |
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