Correlation of MR features and histogram-derived parameters with aggressiveness and outcomes after resection in pancreatic ductal adenocarcinoma
| العنوان: | Correlation of MR features and histogram-derived parameters with aggressiveness and outcomes after resection in pancreatic ductal adenocarcinoma |
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| المؤلفون: | Stefano Gobbo, Alessandro Beleù, Nicolò Cardobi, Isabella Frigerio, Bogdan Mihai Maris, Silvia Ortolani, Mirko D'Onofrio, Riccardo De Robertis, Stefania Montemezzi, Davide Melisi |
| المصدر: | Abdominal Radiology. 45:3809-3818 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Urology, Socio-culturale, Gastroenterology, 030218 nuclear medicine & medical imaging, Correlation, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pancreas, Pathological, Retrospective Studies, Radiological and Ultrasound Technology, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Proportional hazards model, Area under the curve, Hepatology, Prognosis, Pancreatic Neoplasms, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Pancreatic carcinoma, Pancreatic neoplasms, business, Carcinoma, Pancreatic Ductal |
| الوصف: | To evaluate MR-derived histogram parameters in predicting aggressiveness and surgical outcomes in patients with PDAC, by correlating them to pathological features, recurrence-free survival (RFS), and overall survival (OS). Pre-operative MR examinations of 103 patients with PDAC between July 2014 and September 2018 were retrospectively analyzed. Morphologic features and whole-tumor histogram-derived parameters were correlated to pathological features using Fisher’s exact or Mann–Whitney U tests and receiver operating characteristic (ROC) curves were constructed for significant parameters. Cox regression analysis and Kaplan–Meier curves were used to determine the association of clinical–pathological variables, morphological features, and histogram-derived parameters with RFS and OS. T1entropy, ADCentropy, T2kurtosis, and ADCuniformity had the highest area under the curve (AUC) for prediction of vascular infiltration, nodal metastases, microscopic vascular invasion, and peripancreatic fat invasion (.657, .742, .760, and .818, respectively). Poor tumor differentiation (P = 0.002, hazard ratio—HR = 4.08), nodal ratio (P = 0.034, HR 6.95), and ADCmaximum (P = 0.021, HR 1.01) were significant predictors of RFS. Poor tumor differentiation (P = 0.05, HR 2.82), ADCuniformity (P = 0.02, HR 3.32), and arterialentropy (P = 0.02, HR 6.84) were the only significant predictors of death; patients with higher arterialentropy had significantly shorter OS than patients who did not meet this criterion (P = 0.02; median OS 24 vs 31 months). Histogram-derived parameters may predict adverse pathological features in PDACs. High arterialentropy seems to be associated with short OS after surgery in patients with PDAC. |
| تدمد: | 2366-0058 2366-004X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e75fbcfd14119f8333944e2a0f7b27Test https://doi.org/10.1007/s00261-020-02509-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....21e75fbcfd14119f8333944e2a0f7b27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23660058 2366004X |
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