دورية أكاديمية
HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection
| العنوان: | HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection |
|---|---|
| المؤلفون: | Bangham, CRM, Cook, LB, Melamed, A |
| المساهمون: | Medical Research Council (MRC), Wellcome Trust |
| المصدر: | 98 ; 89 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Oncology, HTLV-1, Retrovirus, Leukaemia, Lymphoma, Persistent infection, Clonality, Integration, High-throughput sequencing, VIRUS-TYPE-I, TROPICAL SPASTIC PARAPARESIS, PROVIRAL LOAD, COMBINATION CHEMOTHERAPY, RETROVIRAL INTEGRATION, ASYMPTOMATIC CARRIERS, CIRCULATING CELLS, INTERFERON-ALPHA, GENE-EXPRESSION, DENDRITIC CELLS, Adult, Cytotoxicity, Immunologic, HTLV-I Infections, Human T-lymphotropic virus 1, Humans, Leukemia-Lymphoma, Adult T-Cell, Proviruses |
| الوصف: | Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory diseases and an aggressive malignancy of T lymphocytes known as adult T-cell leukaemia/lymphoma (ATLL). A cardinal feature of HTLV-1 infection is the presence of expanded clones of HTLV-1-infected T cells, which may persist for decades. A high viral burden (proviral load) is associated with both the inflammatory and malignant diseases caused by HTLV-1, and it has been believed that the oligoclonal expansion of infected cells predisposes to these diseases. However, it is not understood what regulates the clonality of HTLV-1 in vivo, that is, the number and abundance of HTLV-1-infected T cell clones. We review recent advances in the understanding of HTLV-1 infection and disease that have come from high-throughput quantification and analysis of HTLV-1 clonality in natural infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1044-579X |
| العلاقة: | Seminars in Cancer Biology; http://hdl.handle.net/10044/1/103313Test; MR/K019090/1; 100291/Z/12/Z |
| DOI: | 10.1016/j.semcancer.2013.11.003 |
| الإتاحة: | https://doi.org/10.1016/j.semcancer.2013.11.003Test http://hdl.handle.net/10044/1/103313Test |
| حقوق: | © 2013 Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.16193987 |
| قاعدة البيانات: | BASE |
| تدمد: | 1044579X |
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| DOI: | 10.1016/j.semcancer.2013.11.003 |