دورية أكاديمية
Growth Differentiation Factor 15 Predicts AM-Cause Morbidity and Mortality in Stable Coronary Heart Disease
| العنوان: | Growth Differentiation Factor 15 Predicts AM-Cause Morbidity and Mortality in Stable Coronary Heart Disease |
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| المؤلفون: | Hagstrom, E, Held, C, Stewart, RAH, Aylward, PE, Budaj, A, Cannon, CP, Koenig, W, Krug-Gourley, S, Mohler, ER, Steg, PG, Tarka, E, Ostlund, O, White, HD, Siegbahn, A, Wallentin, L |
| المصدر: | 333 ; 325 |
| بيانات النشر: | American Association for Clinical Chemistry |
| سنة النشر: | 2016 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, biomarker, bleeding, ischemic heart disease, DUAL ANTIPLATELET THERAPY, FACTOR-15/MACROPHAGE INHIBITORY CYTOKINE-1, OUTCOMES PLATO TRIAL, CARDIOVASCULAR EVENTS, MYOCARDIAL-INFARCTION, PLATELET INHIBITION, CLOPIDOGREL, TICAGRELOR, DISEASE, BIOMARKERS, Medical Laboratory Technology, LONG-TERM RISK, PROGNOSTIC VALUE, COMMUNITY, CARDIOMYOCYTES, ASSOCIATION, DYSFUNCTION, DARAPLADIB, STRESS, Adult, Aged, Coronary Disease, Female |
| الوصف: | Background-—Growth differentiation factor-15 (GDF-15) is related to major bleeding when measured at initial presentation in patients with acute coronary syndromes (ACSs) treated with dual antiplatelet therapy. It is unknown whether follow-up measurements provide additional information. The objective of this study was to investigate whether GDF-15 measured 1 month after an ACS provides additional information beyond the baseline levels with regard to the risk of major bleeding. Methods and Results-—GDF-15 was measured at baseline and at 1 month after an ACS in 4049 patients included in the PLATelet inhibition and patient Outcomes (PLATO) trial. The association between 1-month GDF-15 level and non–coronary artery bypass grafting surgery-related major bleeding was assessed by a multivariable Cox model, adjusting for baseline GDF-15, age, anemia, impaired renal function, history of gastrointestinal bleeding, and sex. Elevated GDF-15 (>1800 ng/L) at 1 month was associated with an increased risk of non-coronary artery bypass grafting-related major bleeding (3.9% versus 1.2%; hazard ratio, 3.38; 95% CI, 1.89–6.06), independent of baseline GDF-15. Patients who had elevated GDF-15 levels at baseline and subsequent nonelevated GDF-15 at 1 month had a similar risk as patients who had nonelevated levels at both measurements. Conclusions-—GDF-15 at 1 month after an ACS is related to the risk of bleeding during DAPT and provides additional information on the bleeding risk beyond baseline GDF-15 levels. GDF-15 levels may therefore be useful as part of decision support concerning long-term antithrombotic treatment in patients post-ACS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1530-8561 |
| العلاقة: | Clinical Chemistry; http://hdl.handle.net/10044/1/51343Test; https://dx.doi.org/10.1373/clinchem.2016.260570Test |
| DOI: | 10.1373/clinchem.2016.260570 |
| الإتاحة: | https://doi.org/10.1373/clinchem.2016.260570Test http://hdl.handle.net/10044/1/51343Test |
| حقوق: | © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made. |
| رقم الانضمام: | edsbas.96EF8484 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15308561 |
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| DOI: | 10.1373/clinchem.2016.260570 |