دورية أكاديمية
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study
| العنوان: | Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study |
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| المؤلفون: | Gong, Q, Gregg, EW, Wang, J, An, Y, Zhang, P, Yang, W, Li, H, Jiang, Y, Shuai, Y, Zhang, B, Zhang, J, Gerzoff, RB, Roglic, G, Hu, Y, Li, G, Bennett, PH |
| المصدر: | 307 ; 300 |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2010 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Diabetic retinopathy, Impaired glucose tolerance, Lifestyle intervention, Nephropathy, Neuropathy, PIMA-INDIANS, VASCULAR-DISEASE, FOLLOW-UP, PREVALENCE, RETINOPATHY, MORTALITY, MELLITUS, PROGRAM, AGE, IGT, Adult, Diabetes Complications, Diabetes Mellitus, Diabetic Nephropathies, Diabetic Neuropathies, Female, Glucose Intolerance, Humans, Life Style, Male, Middle Aged |
| الوصف: | Aims/hypothesis We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. Methods In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to a control group or one of three lifestyle intervention groups (diet, exercise, and diet plus exercise). Active intervention was carried out from 1986 to 1992. In 2006 we conducted a 20 year follow-up study of the original participants to compare the incidence of microvascular complications in the combined intervention group vs the control group. Results Follow-up information was obtained on 542 (94%) of the 577 original participants. The cumulative incidence of severe retinopathy was 9.2% in the combined intervention group and 16.2% in the control group (p = 0.03, log-rank test). After adjusting for clinic and age, the incidence of severe retinopathy was 47% lower in the intervention group than the control group (hazard rate ratio 0.53, 95% CI 0.29–0.99, p = 0.048). No significant differences were found in the incidence of severe nephropathy (hazard rate ratio 1.05, 95% CI 0.16–7.05, intervention vs control, p = 0.96) or in the prevalence of neuropathy (8.6% vs 9.1%, p = 0.89) among the 20 year survivors. Conclusions/interpretation Lifestyle intervention for 6 years in IGT was associated with a 47% reduction in the incidence of severe, vision-threatening retinopathy over a 20 year interval, primarily due to the reduced incidence of diabetes in the intervention group. However, similar benefits were not seen for nephropathy or neuropathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-186X |
| العلاقة: | Diabetologia; http://hdl.handle.net/10044/1/70770Test; https://dx.doi.org/10.1007/s00125-010-1948-9Test |
| DOI: | 10.1007/s00125-010-1948-9 |
| الإتاحة: | https://doi.org/10.1007/s00125-010-1948-9Test http://hdl.handle.net/10044/1/70770Test |
| حقوق: | © Springer-Verlag 2010. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs00125-010-1948-9Test |
| رقم الانضمام: | edsbas.E1BE1A24 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0012186X |
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| DOI: | 10.1007/s00125-010-1948-9 |