دورية أكاديمية
Reproductive factors, exogenous hormone use, and risk of B-cell non-Hodgkin lymphoma in a cohort of women from the European prospective investigation into cancer and nutrition
| العنوان: | Reproductive factors, exogenous hormone use, and risk of B-cell non-Hodgkin lymphoma in a cohort of women from the European prospective investigation into cancer and nutrition |
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| المؤلفون: | Costas, L, Lujan-Barroso, L, Benavente, Y, Allen, NE, Amiano, P, Ardanaz, E, Besson, C, Boeing, H, Bueno-de-Mesquita, B, Cervenka, I, Fortner, RT, Fournier, A, Gunter, M, Harlid, S, Huerta, JM, Jerkeman, M, Jirström, K, Kaaks, R, Karakatsani, A, Khaw, K-T, Kotanidou, A, Lund, E, Masala, G, Mattiello, A, Melin, B, Menéndez, V, Murphy, N, Nieters, A, Overvad, K, Riboli, E, Sacerdote, C, Sánchez, M-J, Schmidt, JA, Sieri, S, Tjønneland, A, Trichopoulou, A, Tumino, R, Vermeulen, R, Weiderpass, E, De Sanjosé, S, Agudo, A, Casabonne, D |
| المساهمون: | Commission of the European Communities |
| المصدر: | 281 ; 274 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | 11 Medical And Health Sciences, 01 Mathematical Sciences, Epidemiology |
| جغرافية الموضوع: | United States |
| الوصف: | The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-6256 |
| العلاقة: | American Journal of Epidemiology; http://hdl.handle.net/10044/1/66434Test; https://dx.doi.org/10.1093/aje/kwy259Test; SP23-CT-2005-006438 |
| DOI: | 10.1093/aje/kwy259 |
| الإتاحة: | https://doi.org/10.1093/aje/kwy259Test http://hdl.handle.net/10044/1/66434Test |
| حقوق: | © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School ofPublic Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
| رقم الانضمام: | edsbas.98F2D30C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14766256 |
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| DOI: | 10.1093/aje/kwy259 |