دورية أكاديمية
Computed tomographic biomarkers in idiopathic pulmonary fibrosis: the future of quantitative analysis
| العنوان: | Computed tomographic biomarkers in idiopathic pulmonary fibrosis: the future of quantitative analysis |
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| المؤلفون: | Wu, X, Kim, GH, Salisbury, ML, Barber, D, Bartholmai, BJ, Brown, KK, Conoscenti, CS, De Backer, J, Flaherty, KR, Gruden, JF, Hoffman, EA, Humphries, SM, Jacob, J, Maher, TM, Raghu, G, Richeldi, L, Ross, BD, Schlenker-Herceg, R, Sverzellati, N, Wells, AU, Martinez, FJ, Lynch, DA, Goldin, J, Walsh, SLF |
| المصدر: | 21 ; 12 |
| بيانات النشر: | American Thoracic Society |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, Respiratory System, General & Internal Medicine, INTERSTITIAL LUNG-DISEASE, HIGH-RESOLUTION CT, FORCED VITAL CAPACITY, END-POINTS, HYPERSENSITIVITY PNEUMONITIS, AUTOMATED QUANTIFICATION, IMAGING BIOMARKERS, TREATMENT TRIALS, CLINICAL-TRIALS, STAGING SYSTEM, biomarker, idiopathic pulmonary fibrosis, quantitative computed tomography, 11 Medical and Health Sciences |
| جغرافية الموضوع: | United States |
| الوصف: | Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with great variability in disease severity and rate of progression. The need for a reliable, sensitive, and objective biomarker to track disease progression and response to therapy remains a great challenge in IPF clinical trials. Over the past decade, quantitative computed tomography (QCT) has emerged as an area of intensive research to address this need. We have gathered a group of pulmonologists, radiologists and scientists with expertise in this area to define the current status and future promise of this imaging technique in the evaluation and management of IPF. In this Pulmonary Perspective, we review the development and validation of six computer-based QCT methods and offer insight into the optimal use of an imaging-based biomarker as a tool for prognostication, prediction of response to therapy, and potential surrogate endpoint in future therapeutic trials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1073-449X |
| العلاقة: | American Journal of Respiratory and Critical Care Medicine; http://hdl.handle.net/10044/1/61127Test; https://doi.org/10.1164/rccm.201803-0444PPTest |
| DOI: | 10.1164/rccm.201803-0444PP |
| الإتاحة: | https://doi.org/10.1164/rccm.201803-0444PPTest http://hdl.handle.net/10044/1/61127Test |
| حقوق: | © 2018 by the American Thoracic Society. |
| رقم الانضمام: | edsbas.83FC49A5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1073449X |
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| DOI: | 10.1164/rccm.201803-0444PP |