دورية أكاديمية
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
| العنوان: | International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci |
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| المؤلفون: | Nievergelt, Caroline M., Maihofer, Adam X., Klengel, Torsten, Atkinson, Elizabeth G., Chen, Chia-Yen, Choi, Karmel W., Coleman, Jonathan R.I., Dalvie, Shareefa, Duncan, Laramie E., Gelernter, Joel, Levey, Daniel F., Logue, Mark W., Polimanti, Renato, Provost, Allison C., Ratanatharathorn, Andrew, Stein, Murray B., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B., Andreassen, Ole Andreas, Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J, Bisson, Jonathan I, Boks, Marco P, Bolger, Elizabeth A, Børglum, Anders D., Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Dale, Anders, Daly, Mark J., Daskalakis, Nikolaos P., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Geuze, Elbert, Gillespie, Charles, Uka, Afërdita Goçi, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevíc, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Junglen, Angela G., Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin E., Linnstaedt, Sarah D., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen Justin, Lyons, Michael J., Maples-Keller, Jessica, Marmar, Charles, Martin, Alicia R., Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., McLeay, Sarah, Mehta, Divya, Milberg, William P., Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben B., Neale, Benjamin M., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O'Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Ripke, Stephan, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Ken, Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S, Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley Kurt, Trapido, Edward, Uddin, Monica, Ursano, Robert J., van den Heuvel, Leigh Luella, van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Wolff, Jonathan D., Yehuda, Rachel, Young, Ross McD., Young, Keith A., Zhao, Hongyu, Zoellner, Lori A., Liberzon, Israel, Ressler, Kerry J., Haas, Magali, Koenen, Karestan C. |
| المصدر: | 2041-1723. |
| سنة النشر: | 2019 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://urn.nb.no/URN:NBN:no-79728Test; Nievergelt, Caroline M. Maihofer, Adam X. Klengel, Torsten Atkinson, Elizabeth G. Chen, Chia-Yen Choi, Karmel W. Coleman, Jonathan R.I. Dalvie, Shareefa Duncan, Laramie E. Gelernter, Joel Levey, Daniel F. Logue, Mark W. Polimanti, Renato Provost, Allison C. Ratanatharathorn, Andrew Stein, Murray B. Torres, Katy Aiello, Allison E. Almli, Lynn M. Amstadter, Ananda B. Andersen, Søren B. Andreassen, Ole Andreas Arbisi, Paul A. Ashley-Koch, Allison E. Austin, S. Bryn Avdibegovic, Esmina Babić, Dragan Bækvad-Hansen, Marie Baker, Dewleen G. Beckham, Jean C. Bierut, Laura J Bisson, Jonathan I Boks, Marco P Bolger, Elizabeth A Børglum, Anders D. Bradley, Bekh Brashear, Megan Breen, Gerome Bryant, Richard A. Bustamante, Angela C. Bybjerg-Grauholm, Jonas Calabrese, Joseph R. Caldas-de-Almeida, José M. Dale, Anders Daly, Mark J. Daskalakis, Nikolaos P. Deckert, Jürgen Delahanty, Douglas L. Dennis, Michelle F. Disner, Seth G. Domschke, Katharina Dzubur-Kulenovic, Alma Erbes, Christopher R. Evans, Alexandra Farrer, Lindsay A. Feeny, Norah C. Flory, Janine D. Forbes, David Franz, Carol E. Galea, Sandro Garrett, Melanie E. Gelaye, Bizu Geuze, Elbert Gillespie, Charles Uka, Afërdita Goçi Gordon, Scott D. Guffanti, Guia Hammamieh, Rasha Harnal, Supriya Hauser, Michael A. Heath, Andrew C. Hemmings, Sian M.J. Hougaard, David Michael Jakovljevíc, Miro Jett, Marti Johnson, Eric Otto Jones, Ian Jovanovic, Tanja Qin, Xue-Jun Junglen, Angela G. Karstoft, Karen-Inge Kaufman, Milissa L. Kessler, Ronald C. Khan, Alaptagin Kimbrel, Nathan A. King, Anthony P. Koen, Nastassja Kranzler, Henry R. Kremen, William S. Lawford, Bruce R. Lebois, Lauren A.M. Lewis, Catrin E. Linnstaedt, Sarah D. Lori, Adriana Lugonja, Bozo Luykx, Jurjen Justin Lyons, Michael J. Maples-Keller, Jessica Marmar, Charles Martin, Alicia R. Martin, Nicholas G. Maurer, Douglas Mavissakalian, Matig R. McFarlane, Alexander McGlinchey, Regina E. McLaughlin, Katie A. McLean, Samuel A. McLeay, Sarah Mehta, Divya Milberg, William P. Miller, Mark W. Morey, Rajendra A. Morris, Charles Phillip Mors, Ole Mortensen, Preben B. Neale, Benjamin M. Nelson, Elliot C. Nordentoft, Merete Norman, Sonya B. O'Donnell, Meaghan Orcutt, Holly K. Panizzon, Matthew S. Peters, Edward S. Peterson, Alan L. Peverill, Matthew Pietrzak, Robert H. Polusny, Melissa A. Rice, John P. Ripke, Stephan Risbrough, Victoria B. Roberts, Andrea L. Rothbaum, Alex O. Rothbaum, Barbara O. Roy-Byrne, Peter Ruggiero, Ken Rung, Ariane Rutten, Bart P.F. Saccone, Nancy L. Sanchez, Sixto E. Schijven, Dick Seedat, Soraya Seligowski, Antonia V. Seng, Julia S. Sheerin, Christina M. Silove, Derrick Smith, Alicia K. Smoller, Jordan W. Sponheim, Scott R. Stein, Dan J. Stevens, Jennifer S Sumner, Jennifer A. Teicher, Martin H. Thompson, Wesley Kurt Trapido, Edward Uddin, Monica Ursano, Robert J. van den Heuvel, Leigh Luella van Hooff, Miranda Vermetten, Eric Vinkers, Christiaan H. Voisey, Joanne Wang, Yunpeng Wang, Zhewu Werge, Thomas Williams, Michelle A. Williamson, Douglas E. Winternitz, Sherry Wolf, Christiane Wolf, Erika J. Wolff, Jonathan D. Yehuda, Rachel Young, Ross McD. Young, Keith A. Zhao, Hongyu Zoellner, Lori A. Liberzon, Israel Ressler, Kerry J. Haas, Magali Koenen, Karestan C. . International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications. 2019, 10:4558, 1-16; http://hdl.handle.net/10852/76632Test; 1754983; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=10:4558&rft.spage=1&rft.date=2019; Nature Communications; 10; https://doi.org/10.1038/s41467-019-12576-wTest; URN:NBN:no-79728; Fulltext https://www.duo.uio.no/bitstream/handle/10852/76632/2/International%2Bmeta-analysis%2Bof%2BPTSD%2Bgenome-wide%2Bassociation%2Bstudies%2Bidentifies%2Bsex-%2Band%2Bancestry-specific%2Bgenetic%2Brisk%2Bloci.pdfTest |
| DOI: | 10.1038/s41467-019-12576-w |
| الإتاحة: | https://doi.org/10.1038/s41467-019-12576-wTest http://hdl.handle.net/10852/76632Test http://urn.nb.no/URN:NBN:no-79728Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.8B511FB7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-019-12576-w |
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