المؤلفون: Xiaojuan He, Ke Zhou, Dongmei Jia, Aiping Lu, Yong Tan, Miao Jiang, Guang Zheng, Shanshan Shen, Yaoxian Wang

المصدر: BIBM

مصطلحات موضوعية: chemistry.chemical_compound, Bioinformatics analysis, chemistry, business.industry, otorhinolaryngologic diseases, medicine, Molecular mechanism, Gastrodin, medicine.symptom, Bioinformatics, business, Tinnitus

الوصف: Tinnitus is the most common medical symptom that can be debilitating. Chinese herbal medicines (CHMs) play important roles in tinnitus treatment. This study analyzed the most frequently prescribed herbs used to treat tinnitus and the molecular mechanisms of therapeutic effects of these CHMs by text mining and bioinformatics technique. Results showed that pinellia ternate (Banxia) and gastrodin (Tianma) are the most frequently prescribed CHMs for treatment tinnitus. The molecular mechanisms of therapeutic effects of two CHMs were focused on sertoli cell-sertoli cell juntion signaling and NRF2-mediated oxidative stress response signaling. Integrative text mining and bioinformatics analysis may be a promising approach to find new drug and decipher their molecular mechanism intuitively.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::438bb4c099be4d622404e5cf47fdc8eeTest
https://doi.org/10.1109/bibm.2014.6999348Test

المؤلفون: Guang Zheng, Shanshan Shen, Aiping Lu, Yaoxian Wang, Miao Jiang, Dongmei Jia

المصدر: BIBM

مصطلحات موضوعية: medicine.medical_specialty, Massage, Magnet therapy, business.industry, Traditional Chinese medicine, Bioinformatics, medicine.disease, Endocrinology, Text mining, Breast cancer, Internal medicine, medicine, Mammary gland hyperplasia, Acupuncture, Endocrine system, business

الوصف: Mammary gland hyperplasia (MGH) is a kind of endocrine disorder diseases, which is usually characterized by lump and pain in breast and an increased risk event of breast cancer. The complementary therapies of Traditional Chinese Medicine (TCM) play important roles in MGH treatment. This study analyzed the application of the TCM external therapy and food therapy by text mining. Subsequently, suitable techniques and methods which were frequently used on MGH treatment were explored. Results showed that external application of Chinese herb medicine, acupuncture, massage, catgut embedding, and magnet therapy were the top 5 TCM external therapy techniques, while fritillaria Oyster, alga, trionyx, kelp, arrowhead, pseudo-ginseng, lemon, leonurus, and hawthorn were the top 10 foods used for MGH treatment. The combinations of external therapy techniques were demonstrated in network, so does the combinations of the foods. The results provided good references for both clinical practice and basic research.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::204af9f939fe20d270fa900177276977Test
https://doi.org/10.1109/bibm.2014.6999347Test

المؤلفون: Aiping Lu, Zekun Ning, Hongtao Guo, Ning Zhao, Yaoxian Wang, Bai Jingan, Shanshan Shen, Dongmei Jia, Xiaojuan He, Miao Jiang, Cheng Lu, Yong Tan, Jing Yang, Mengmeng Song, Guang Zheng

المصدر: BIBM

مصطلحات موضوعية: medicine.medical_specialty, Lower grade, Text mining, Medical treatment, business.industry, Internal medicine, medicine, Traditional Chinese medicine, Medical prescription, Zusanli, business, Coronary heart disease, Selection (genetic algorithm)

الوصف: Acupoint application therapy is one of the Traditional Chinese medicine (TCM) external therapies, which has been used for coronary heart disease (CHD) treatment for a long time. The prescription of acupoint application therapy includes both Chinese herbal medicines (CHMs) and acupoints. This study aims to reveal the basic rules of acupoint selection in acupoint application therapy on CHD treatment by text mining study. Results showed that on CHD treatment, the most frequently used acupoint was Danzhong (RN17), followed by Xinshu (BL15), Neiguan (PC6), Zusanli (ST36) and Zhiyang (DU9). Acupoints closing to the heart or with specific functions were more frequently used. Moreover, Xinshu, Danzhong and Neiguan were of the top 3 relationships with other acupoints, while Zusanli and Sanyinjiao (SP6) were in the lower grade. The combination of Xinshu-Danzhong-Neiguan could be regard as the basic acupoint prescription of acupoint application therapy on CHD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0746a697cef10d237b77cc64f71bbc7eTest
https://doi.org/10.1109/bibm.2014.6999321Test