دورية أكاديمية
HIV-1 DNA predicts disease progression and post-treatment virological control.
| العنوان: | HIV-1 DNA predicts disease progression and post-treatment virological control. |
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| المؤلفون: | Williams, JP, Hurst, J, Stoehr, W, Robinson, N, Brown, H, Fisher, M, Kinloch, S, Cooper, D, Schechter, M, Tambussi, G, Fidler, S, Carrington, M, Babiker, A, Weber, J, Koelsch, KK, Kelleher, AD, Phillips, RE, Frater, J |
| المساهمون: | Wellcome Trust, National Institute for Health Research |
| المصدر: | 16 ; 1 |
| بيانات النشر: | eLife Sciences Publications Ltd |
| سنة النشر: | 2014 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, ANTIRETROVIRAL THERAPY, LATENT RESERVOIR, INFECTION, VIREMIA, INTERRUPTION, VIRUS, LEVEL, CELLS, TIME, CESSATION, HIV-1, cure, human, human biology, infectious disease, medicine, microbiology, primary infection, reservoir, Highly Active, Biomarkers, CD4 Lymphocyte Count, Demography, Disease Progression, Female, HIV Infections |
| الوصف: | In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | eLife; http://hdl.handle.net/10044/1/21629Test; 069598/Z/02/Z; NF-SI-0507-10313 |
| DOI: | 10.7554/eLife.03821 |
| الإتاحة: | https://doi.org/10.7554/eLife.03821Test http://hdl.handle.net/10044/1/21629Test |
| حقوق: | © Copyright Williams et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.948BD4E7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.03821 |