دورية أكاديمية
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
| العنوان: | Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study |
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| المؤلفون: | Reyes, LF, Murthy, S, Garcia-Gallo, E, Merson, L, Ibanez-Prada, ED, Rello, J, Fuentes, Y, Martin-Loeches, I, Bozza, F, Duque, S, Taccone, FS, Fowler, RA, Kartsonaki, C, Goncalves, BP, Citarella, BW, Aryal, D, Burhan, E, Cummings, MJ, Delmas, C, Diaz, R, Figueiredo-Mello, C, Hashmi, M, Panda, PK, Jimenez, MP, Rincon, DFB, Thomson, D, Nichol, A, Marshall, JC, Olliaro, PL |
| المصدر: | 16 ; 1 |
| بيانات النشر: | BMC |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| الوصف: | Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1364-8535 |
| العلاقة: | Critical Care (UK); http://hdl.handle.net/10044/1/105233Test |
| DOI: | 10.1186/s13054-022-04155-1 |
| الإتاحة: | https://doi.org/10.1186/s13054-022-04155-1Test http://hdl.handle.net/10044/1/105233Test |
| حقوق: | © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecoTest mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.866EEE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13648535 |
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| DOI: | 10.1186/s13054-022-04155-1 |