دورية أكاديمية
Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials ; ENEngelskEnglishEffects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials
| العنوان: | Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials ; ENEngelskEnglishEffects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials |
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| المؤلفون: | Al-Shahi Salman, Rustam, Stephen, Jacqueline, Tierney, Jayne F, Lewis, Steff C, Newby, David E, Parry-Jones, Adrian R, White, Philip M, Connolly, Stuart J, Benavente, Oscar R, Dowlatshahi, Dar, Cordonnier, Charlotte, Viscoli, Catherine M, Sheth, Kevin N, Kamel, Hooman, Veltkamp, Roland, Larsen, Kristin Tveitan, Hofmeijer, Jeannette, Kerkhoff, Henk, Schreuder, Floris H B M, Shoamanesh, Ashkan, Klijn, Catharina J M, van der Worp, H Bart, Song, Lili, Wyller, Torgeir Bruun, Rønning, Ole Morten, Ihle-Hansen, Hege Beathe, Sandset, Else Charlotte, Carlsson, Maria Kristin |
| المصدر: | 1474-4422. |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Background The safety and efficacy of oral anticoagulation for prevention of major adverse cardiovascular events in people with atrial fibrillation and spontaneous intracranial haemorrhage are uncertain. We planned to estimate the effects of starting versus avoiding oral anticoagulation in people with spontaneous intracranial haemorrhage and atrial fibrillation. Methods In this prospective meta-analysis, we searched bibliographic databases and trial registries using the strategies of a Cochrane systematic review (CD012144) on June 23, 2023. We included clinical trials if they were registered, randomised, and included participants with spontaneous intracranial haemorrhage and atrial fibrillation who were assigned to either start long-term use of any oral anticoagulant agent or avoid oral anticoagulation (ie, placebo, open control, another antithrombotic agent, or another intervention for the prevention of major adverse cardiovascular events). We assessed eligible trials using the Cochrane Risk of Bias tool. We sought data for individual participants who had not opted out of data sharing from chief investigators of completed trials, pending completion of ongoing trials in 2028. The primary outcome was any stroke or cardiovascular death. We used individual participant data to construct a Cox regression model of the time to the first occurrence of outcome events during follow-up in the intention-to-treat dataset supplied by each trial, followed by meta-analysis using a fixed-effect inverse-variance model to generate a pooled estimate of the hazard ratio (HR) with 95% CI. This study is registered with PROSPERO, CRD42021246133. Findings We identified four eligible trials; three were restricted to participants with atrial fibrillation and intracranial haemorrhage (SoSTART [NCT03153150 ], with 203 participants) or intracerebral haemorrhage (APACHE-AF [NCT02565693], with 101 participants, and NASPAF-ICH [NCT02998905], with 30 participants), and one included a subgroup of participants with previous intracranial ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Al-Shahi Salman, Rustam Stephen, Jacqueline Tierney, Jayne F Lewis, Steff C Newby, David E Parry-Jones, Adrian R White, Philip M Connolly, Stuart J Benavente, Oscar R Dowlatshahi, Dar Cordonnier, Charlotte Viscoli, Catherine M Sheth, Kevin N Kamel, Hooman Veltkamp, Roland Larsen, Kristin Tveitan Hofmeijer, Jeannette Kerkhoff, Henk Schreuder, Floris H B M Shoamanesh, Ashkan Klijn, Catharina J M van der Worp, H Bart Song, Lili Wyller, Torgeir Bruun Rønning, Ole Morten Ihle-Hansen, Hege Beathe Sandset, Else Charlotte Carlsson, Maria Kristin . Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials. Lancet Neurology. 2023, 22(12), 1140-1149; http://hdl.handle.net/10852/106404Test; 2208076; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Lancet Neurology&rft.volume=22&rft.spage=1140&rft.date=2023; Lancet Neurology; 22; 12; 1140; 1149; https://doi.org/10.1016/S1474-4422Test(23)00315-0 |
| DOI: | 10.1016/S1474-4422(23)00315-0 |
| الإتاحة: | https://doi.org/10.1016/S1474-4422Test(23)00315-0 http://hdl.handle.net/10852/106404Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C8580EB2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1474-4422(23)00315-0 |
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